Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

M. Hedidi (1, 2) , W. Erb (2) , G. Bentabed-Ababsa (1) , Floris Chevallier (2) , L. Picot (3) , V. Thiéry (3) , S. Bach (4) , S. Ruchaud (4) , T. Roisnel (2) , V. Dorcet (2) , F. Mongin (2)

1 Laboratoire de Synthèse Organique Appliquée
2 ISCR - Institut des Sciences Chimiques de Rennes
3 LIENSs - LIttoral ENvironnement et Sociétés
4 P3H - Phophorylation de protéines et Pathologies Humaines

Keywords: Pyridine; Azole; N-Arylation; Copper; Antiproliferative activity

Domains: Chemical Sciences; Medicinal Chemistry

M. Hedidi, W. Erb, G. Bentabed-Ababsa, Floris Chevallier, L. Picot, et al.. Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells. Tetrahedron, 2016, 72 (41), pp.6467--6476. ⟨10.1016/j.tet.2016.08.056⟩. ⟨hal-01381138⟩