Nomogram for individualized prediction of hepatocellular carcinoma occurrence in hepatitis C virus cirrhosis (ANRS CO12 CirVir) - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Hepatology Année : 2016

Nomogram for individualized prediction of hepatocellular carcinoma occurrence in hepatitis C virus cirrhosis (ANRS CO12 CirVir)

1 U1162 - Génomique Fonctionnelle des Tumeurs Solides
2 Hôpital Jean Verdier [AP-HP]
3 Service de santé publique [Mondor]
4 ANRS - Agence Nationale de Recherches sur le Sida et les Hépatites Virales
5 Hôpital Beaujon [AP-HP]
6 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
7 Service d'hépatologie médicale [CHU Cochin]
8 IP - Institut Pasteur [Paris]
9 CHRU Montpellier - Hôpital Saint Eloi
10 Hôpital Haut-Lévêque [CHU Bordeaux]
11 Institut Arnault Tzanck
12 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
13 IBCP - Institut de biologie et chimie des protéines [Lyon]
14 Hôpital Avicenne [AP-HP]
15 CHU Nice - Centre Hospitalier Universitaire de Nice
16 C3M - Centre méditerranéen de médecine moléculaire
17 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
18 Département de Gastroentérologie et hépatologie
19 Hôpital Charles Nicolle [Rouen]
20 ICAT - SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques
21 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
22 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
23 Hôpital Saint-Joseph [Marseille]
24 Hôpital Claude Huriez [Lille]
25 Hôpital Saint-André
26 CHU Estaing [Clermont-Ferrand]
27 CHU Saint-Antoine [AP-HP]
28 CHU Henri Mondor [Créteil]
29 CHU Tenon [AP-HP]
30 Hôpital Paul Brousse
31 CHU Trousseau [Tours]
32 CHIAP - Centre Hospitalier d'Aix en Provence [Aix-en-Provence]
33 CHU Caen
34 CHU Pitié-Salpêtrière [AP-HP]
35 Centre Hospitalier Le Mans (CH Le Mans)
36 CHU de Poitiers - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
37 IMM - Institut Mutualiste de Montsouris
38 CHU Amiens-Picardie
39 AP-HP Hôpital universitaire Robert-Debré [Paris]
40 Hôpital Foch [Suresnes]
Richard Layese
Dominique Larrey
Denis Ouzan
Armand Abergel
Lawrence Serfaty
Thông Dao
Christos Christidis
David Zucman
Vincent Di Martino
  • Fonction : Auteur

Résumé

Unlabelled - The aim of this work was to develop an individualized score for predicting hepatocellular carcinoma (HCC) in patients with hepatitis C (HCV)-compensated cirrhosis. Among 1,323 patients with HCV cirrhosis enrolled in the French prospective ANRS CO12 CirVir cohort, 720 and 360 were randomly assigned to training and validation sets, respectively. Cox's multivariate model was used to predict HCC, after which a nomogram was computed to assess individualized risk. During follow-up (median, 51.0 months), 103 and 39 patients developed HCC in the training and validation sets, respectively. Five variables were independently associated with occurrence of HCC: age > 50 years (hazard ratio [HR], 1.94; 95% confidence interval [CI], 1.16; 3.25; P = 0.012); past excessive alcohol intake (HR, 1.55; 95% CI, 1.02; 2.36; P = 0.041); low platelet count (<100 Giga/mm(3) : HR, 2.70; 95% CI, 1.62; 4.51; P < 0.001; [100; 150] Giga/mm(3) : HR, 1.87; 95% CI, 1.10; 3.18; P = 0.021); gamma-glutamyl transpeptidase above the upper limit of normal (HR, 1.96; 95% CI, 1.11; 3.47; P = 0.021); and absence of a sustained virological response during follow-up (HR, 3.02; 95% CI, 1.67; 5.48; P < 0.001). An 11-point risk score was derived from the training cohort and validated in the validation set. Based on this score, the population was stratified into three groups, in which HCC development gradually increased, from 0% to 30.1% at 5 years for patients with the lowest (≤3) and highest (≥8) scores (P < 0.001). Using this score, a nomogram was built enabling individualized prediction of HCC occurrence at 1, 3, and 5 years. Conclusion - This HCC score can accurately predict HCC at an individual level in French patients with HCV cirrhosis. (Hepatology 2016;64:1136-1147).
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Dates et versions

hal-01381662 , version 1 (26-10-2016)

Identifiants

Citer

Nathalie Ganne-Carrié, Richard Layese, Valérie Bourcier, Carole Cagnot, Patrick Marcellin, et al.. Nomogram for individualized prediction of hepatocellular carcinoma occurrence in hepatitis C virus cirrhosis (ANRS CO12 CirVir). Hepatology, 2016, 64 (4), pp.1136-1147. ⟨10.1002/hep.28702⟩. ⟨hal-01381662⟩
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