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Colonic anastomoses and non-steroidal anti-inflammatory drugs

Abstract : Nonsteroidal anti-inflammatory drugs (NSAID) play an important role in the treatment of post-operative pain, particularly in the context of enhanced recovery after colorectal surgery. Several recent articles have suggested that NSAID may have a deleterious effect on colo-colic or colo-rectal anastomoses. The aim of this review is to analyze the evidence based on meta-analyses and cohort studies in the literature. A systematic review of clinical studies identified twelve studies including two meta-analyses and ten comparative cohort studies that included a large number of patients. The data in these studies are heterogeneous, often biased, and do not permit a formal recommendation based on a high level of evidence. The main conclusion of this review is that the balance of benefit vs. risk (analgesic effect/risk of anastomotic disruption) is acceptable; it appears (with a low level of evidence) that a prescription of NSAID for 48 h after surgery may be recommended for elective colon surgery. Nevertheless, it is important to respect the specific contra-indications of NSAID and avoid post-operative NSAID use if there are risk factors for anastomotic leakage: advanced age, malnutrition, severe co-morbidities, intra-operative difficulties. (C) 2016 Elsevier Masson SAS. All rights reserved.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01395128
Contributor : Laurent Jonchère <>
Submitted on : Thursday, November 10, 2016 - 2:58:48 PM
Last modification on : Thursday, June 18, 2020 - 9:29:11 AM

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K. Slim, J. Joris, H. Beloeil. Colonic anastomoses and non-steroidal anti-inflammatory drugs. Journal of Visceral Surgery, Elsevier, 2016, 153 (4), pp.269--275. ⟨10.1016/j.jviscsurg.2016.06.011⟩. ⟨hal-01395128⟩

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