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Prevalence and characteristics of acid gastro-oesophageal reflux disease in Jackhammer oesophagus

Abstract : Background: An association between acid gastro-oesophageal reflux disease (GERD) and Jackhammer oesophagus has been suggested. Aim: To assess the prevalence and characteristics of acid-GERD in Jackhammer oesophagus and the efficacy of proton pump inhibitors. Methods: Data and outcomes of patients with Jackhammer oesophagus were assessed. Two groups were compared: (i) GERD, defined by endoscopic oesophagitis or by an increase in acid exposure time or by an acid-hypersensitive oesophagus and (ii) non-GERD defined by normal oesophageal acid exposure without acid-hypersensitive oesophagus. Results: Among the 1994 high-resolution manometries performed, 44 Jackhammer oesophagus (2.2%) were included (sex ratio M/F: 19/25; median age: 66 [61-75] years). Nineteen patients (43.2%) had GERD, 16 (36.4%) had no GERD and 9 patients (20.4%) were undetermined. Dysphagia was the predominant symptom (37/43 (86%)). After a median follow-up of 25.3 months [9.6-31.4], dysphagia was improved in 22/36 (61.1%) patients. Dysphagia improvement as well as other symptoms improvement was not associated with GERD status or proton-pump inhibitors use. Conclusion: The prevalence of GERD is high among patients with Jackhammer oesophagus. The rates of symptom improvement in Jackhammer oesophagus were high regardless of the use of proton-pump inhibitors treatment or of the presence of GERD. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01395133
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Submitted on : Thursday, November 10, 2016 - 2:59:01 PM
Last modification on : Wednesday, May 16, 2018 - 11:24:07 AM

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Anne-Laure Mallet, Alain Ropert, Guillaume Bouguen, Laurent Siproudhis, Dominique Boutroux, et al.. Prevalence and characteristics of acid gastro-oesophageal reflux disease in Jackhammer oesophagus. Digestive and Liver Disease, WB Saunders, 2016, 48 (10), pp.1136--1141. ⟨10.1016/j.dld.2016.06.030⟩. ⟨hal-01395133⟩

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