Sofosbuvir-based treatment of hepatitis C with severe fibrosis (METAVIR F3/F4) after liver transplantation results from the CO23 ANRS CUPILT study

Jerome Dumortier; V. Leroy; C. Duvoux; V. Lédinghen; C. Francoz; P. Houssel-Debry; S. Radenne; L. d'Alteroche; C. Fougerou-Leurent; V. Canva; V. Martino; F. Conti; N. Kamar; C. Moreno; P. Lebray; A. Tran; C. Besch; A. Diallo; A. Rohel; E. Rossignol; A. Abergel; D. Botta-Fridlund; A. Coilly; D. Samuel; J.-C. Duclos-Vallée; G.-P. Pageaux

doi:10.1002/lt.24505

Sofosbuvir-based treatment of hepatitis C with severe fibrosis (METAVIR F3/F4) after liver transplantation results from the CO23 ANRS CUPILT study

Jerome Dumortier ^{1, *} V. Leroy ² C. Duvoux ³ V. Lédinghen ^{4, 5} C. Francoz ⁶ P. Houssel-Debry ^{7, 8} S. Radenne ¹ L. d'Alteroche ⁹ C. Fougerou-Leurent ^{7, 8} V. Canva ¹⁰ V. Martino ¹¹ F. Conti ¹² N. Kamar ^{13, 14} C. Moreno ¹⁵ P. Lebray ¹² A. Tran ^{16, 17} C. Besch ¹⁸ A. Diallo ¹⁹ A. Rohel ¹⁹ E. Rossignol ⁷ A. Abergel ^{20, 21} D. Botta-Fridlund ²² A. Coilly ^{23, 24} D. Samuel ^{24, 23} J.-C. Duclos-Vallée ^{23, 24} G.-P. Pageaux ²⁵

* Corresponding author

1 Département d'hépatologie

2 Epidémiologie pronostique des cancers et affections graves

3 Service d'Hépatologie, Hôpital Henri Mondor, AP-HP, Créteil, France.

4 Hôpital Haut-Lévêque [CHU Bordeaux]

5 Physiopathologie du cancer du foie

6 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation

7 CIC - Centre d'Investigation Clinique [Rennes]

8 CHU Pontchaillou [Rennes]

9 Service d'hépato-gastroentérologie, Centre Hospitalier Universitaire Trousseau, Tours, France.

10 Services de Maladies de l'Appareil Digestif, Hôpital Claude Huriez, Centre Hospitalier Universitaire de Lille, Lille, France

11 Service d'Hépatologie, Hôpital Jean Minjoz, Centre Hospitalier Universitaire de Besançon, Université de Franche Comté

12 CR Saint-Antoine - Centre de Recherche Saint-Antoine

13 I2MR - Institut de médecine moléculaire de Rangueil

14 Department of Multiorgan Transplantation

15 ULB - Hôpital Erasme, Université Libre de Bruxelles

16 CHU Nice - Centre Hospitalier Universitaire de Nice

17 C3M - Centre méditerranéen de médecine moléculaire

18 Service de Transplantation, Centre Hospitalier Universitaire de Strasbourg,

19 Unité de la recherche fondamentale et clinique sur l' hépatite virale, France Recherche Nord & Sud Asdi-VIH Hépatites, Agence Nationale de Recherche sur le Sida

20 CHU Estaing [Clermont-Ferrand]

21 ISIT - Image Science for Interventional Techniques

22 Service d'hépato-gastroentérologie, Hôpital de la Conception, AP-HM, Marseille

23 Physiopathologie et traitement des maladies du foie

24 Hôpital Paul Brousse

25 Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi]

Abstract : Recurrence of hepatitis C virus (HCV) after liver transplantation (LT) can rapidly lead to liver graft cirrhosis and, therefore, graft failure and retransplantation or death. The aim of the present study was to assess efficacy and tolerance of sofosbuvir (SOF)–based regimens for the treatment of HCV recurrence in patients with severe fibrosis after LT. The Compassionate Use of Protease Inhibitors in Viral C Liver Transplantation (CULPIT) study is a prospective multicenter cohort including patients with HCV recurrence following LT treated with second generation direct antivirals. The present study focused on patients included between October 2013 and November 2014 and diagnosed with HCV recurrence and liver graft extensive fibrosis (METAVIR F3/F4). A SOF-based regimen was administered to 125 patients fulfilling inclusion criteria. The median delay from LT was 95.9 ± 69.6 months. The characteristics of patients were as follows: mean age, 59.4 ± 9.0 years; 78.4% male; infected by HCV genotype 1: 78.2%, mean HCV RNA: 6.1 ± 1.0 log10 IU/mL. Eighty patients had failed previous post-LT antiviral therapy (64.0%) including triple therapy with first generation protease inhibitors in 19 (15.2%) patients. The main combination regimen was SOF/daclatasvir (73.6%). Ribavirin was used in 60 patients. Sustained virological response 12 weeks after treatment was 92.8% (on an intention-to-treat basis); 7 patients with virological failure were observed. Serious adverse events occurred in 25.6% of the patients during antiviral treatment. During antiviral treatment and follow-up, 3 patients were retransplanted and 4 patients died. In conclusion, SOF-based antiviral treatment shows very promising results in patients with HCV recurrence and severe fibrosis after LT. Liver Transplantation 22 1367–1378 2016 AASLD. © 2016 by the American Association for the Study of Liver Diseases

Keywords : transplantation hepatitis C virus sofosbuvir-based treatment severe fibrosis (METAVIR F3/F4)

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Human health and pathology

Life Sciences [q-bio] / Human health and pathology / Hépatology and Gastroenterology

Life Sciences [q-bio] / Pharmaceutical sciences / Medication

Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01397762
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, January 4, 2017 - 4:22:09 PM
Last modification on : Tuesday, February 25, 2020 - 10:23:27 AM

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