Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

J. Barbeau; L. Lemiègre; A. Quelen; V. Malard; H. Gao; C. Gonçalves; M. Berchel; Paul-Alain Jaffres; C. Pichon; P. Midoux; T. Benvegnu

doi:10.1016/j.carres.2016.10.003

Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

J. Barbeau ¹ L. Lemiègre ¹ A. Quelen ¹ V. Malard ² H. Gao ² C. Gonçalves ² M. Berchel ³ Paul-Alain Jaffres ³ C. Pichon ² P. Midoux ² T. Benvegnu ¹

1 ISCR - Institut des Sciences Chimiques de Rennes

2 CBM - Centre de biophysique moléculaire

3 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique

Abstract : An archaeal diether lipid possessing a tri-antenna of α-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. This new mannosylated lipid inserted in liposomes would show both DC-targeting and adjuvant properties thanks to the TriMan structure and the diether tail part, respectively.

Keywords : Archaeal trimannosyl lipid Liposomes Dendritic cell binding Mannose receptor

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

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Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

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Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

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