Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes

J. Barbeau 1 L. Lemiègre 1 A. Quelen 1 V. Malard 2 H. Gao 2 C. Gonçalves 2 M. Berchel 3 Paul-Alain Jaffres 3 C. Pichon 2 P. Midoux 2 T. Benvegnu 1
1 ISCR - Institut des Sciences Chimiques de Rennes
2 CBM - Centre de biophysique moléculaire
3 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
Abstract : An archaeal diether lipid possessing a tri-antenna of α-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. This new mannosylated lipid inserted in liposomes would show both DC-targeting and adjuvant properties thanks to the TriMan structure and the diether tail part, respectively.
Keywords : Archaeal trimannosyl lipid Liposomes Dendritic cell binding Mannose receptor
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Submitted on : Monday, November 21, 2016 - 9:41:23 AM
Last modification on : Monday, June 3, 2019 - 11:34:08 AM

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J. Barbeau, L. Lemiègre, A. Quelen, V. Malard, H. Gao, et al.. Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes. Carbohydrate Research, Elsevier, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩. ⟨hal-01398046⟩

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