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Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France

A. Rougemont 1, 2, * J. Kaplon 1 C. Fremy 1 S. Aho 3 P. Pothier 1 M.-C. Legrand-Guillien 4 A. Minoui-Tran 4 C. Payan 4 A. Vabret 5 L. Mendes-Martins 6 M. Chouchane 3 R. Maudinas 3 F. Huet 3 F. Dubos 7 D. Hober 7 M. Lazrek 7 C. Bouquignaud 8 A. Decoster 8 S. Alain 9 J. Languepin 9 Y Gillet 10 B. Lina 11 Y. Mekki 10 F. Morfin-Sherpa 10 A. Guigon 12 J. Guinard 12 V. Foulongne 13, 14 M. Rodiere 13 V. Avettand-Fenoel 15 S. Bonacorsi 15 A. Garbarg-Chenon 15 D. Gendrel 15 P. Lebon 15 M. Lorrot 15 P. Mariani 15 J.-F. Meritet 15 A. Schnuriger 15 G. Agius 16 A. Beby-Defaux 16 D. Oriot 16 R. Colimon 17 G. Lagathu 17 O. Mory 18 S. Pillet 18 B. Pozzetto 18 J.-L. Stephan 18
Abstract : Group A rotavirus (RVA) is the leading cause of acute gastroenteritis in young children worldwide. A prospective surveillance network has been set up to investigate the virological and clinical features of RVA infections and to detect the emergence of potentially epidemic strains in France. From 2009 to 2014, RVA-positive stool samples were collected from 4800 children <5 years old attending the paediatric emergency units of 16 large hospitals. Rotaviruses were then genotyped by RT-PCR with regard to their outer capsid proteins VP4 and VP7. Genotyping of 4708 RVA showed that G1P[8] strains (62.2%) were predominant. The incidence of G9P[8] (11.5%), G3P[8] (10.4%) and G2P[4] (6.6%) strains varied considerably, whereas G4P[8] (2.7%) strains were circulating mostly locally. Of note, G12P[8] (1.6%) strains emerged during the seasons 2011–12 and 2012–13 with 4.1% and 3.0% prevalence, respectively. Overall, 40 possible zoonotic reassortants, such as G6 (33.3%) and G8 (15.4%) strains, were detected, and were mostly associated with P[6] (67.5%). Analysis of clinical records of 624 hospitalized children and severity scores from 282 of them showed no difference in clinical manifestations or severity in relation to the genotype. The relative stability of RVA genotypes currently co-circulating and the large predominance of P[8] type strains may ensure vaccine effectiveness in France. The surveillance will continue to monitor the emergence of new reassortants that might not respond to current vaccines, all the more so as all genotypes can cause severe infections in infants. © 2016 European Society of Clinical Microbiology and Infectious Diseases
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A. Rougemont, J. Kaplon, C. Fremy, S. Aho, P. Pothier, et al.. Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France. Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2016, 22 (8), pp.737.e9--737.e15. ⟨10.1016/j.cmi.2016.05.025⟩. ⟨hal-01398377⟩

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