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The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucemie de l'Enfant et de L'Adolescent Study

Sandrine Visentin 1, * Pascal Auquier 2 Yves Bertrand 3 André Baruchel 4 Marie-Dominique Tabone 5 Cécile Pochon 6 Charlotte Jubert 7 Maryline Poiree 8 Virginie Gandemer 9, 10 Anne Sirvent 11 Jacinthe Bonneau 12, 10 Catherine Paillard 13 Claire Freycon Justyna Kanold 14 Virginie Villes 2 Julie Berbis 2 Claire Oudin 15, 2 Claire Galambrun 16 Isabelle Pellier 17 Genevieve Plat 18 Hervé Chambost 16 Guy Leverger 5 Jean-Hugues Dalle 19 Gérard Michel 20
Abstract : We compared the long-term impact of donor type (sibling donor [SD] versus matched unrelated donor [MUD] or umbilical cord blood [UCB]) on late side effects and quality of life (QoL) in childhood acute leukemia survivors treated with hematopoietic stem cell transplantation. We included 314 patients who underwent transplantation from 1997 to 2012 and were enrolled in the multicenter French Leucemie de l'Enfant et de L'Adolescent ("Leukemia in Children and Adolescents") cohort. More than one-third of the patients were adults at last visit; mean follow-up duration was 6.2 years. At least 1 late effect was observed in 284 of 314 patients (90.4%). The average number of adverse late effects was 2.1 +/- 1, 2.4 +/- 2, and 2.4 +/- 2 after SD, MUD, and UCB transplantation, respectively. In a multivariate analysis, considering the SD group as the reference, we did not detect an impact of donor type for most sequelae, with the exception of increased risk of major growth failure after MUD transplantation (odds ratio [OR], 2.42) and elevated risk of osteonecrosis after UCB transplantation (OR, 4.15). The adults and children's parents reported comparable QoL among the 3 groups. Adult patient QoL scores were lower than age- and sex-matched French reference scores for almost all dimensions. We conclude that although these patients are heavily burdened by long-term complications, donor type had a very limited impact on their long-term health status and QoL.
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Submitted on : Wednesday, March 28, 2018 - 4:19:18 PM
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Sandrine Visentin, Pascal Auquier, Yves Bertrand, André Baruchel, Marie-Dominique Tabone, et al.. The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucemie de l'Enfant et de L'Adolescent Study. Biology of Blood and Marrow Transplantation, Elsevier, 2016, 22 (11), pp.2003--2010. ⟨10.1016/j.bbmt.2016.08.004⟩. ⟨hal-01415935⟩

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