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Turning tumour cells into antigen presenting cells: The next step to improve cancer immunotherapy?

Abstract : Downregulation/loss of the antigen presentation is a major immune escape mechanism in cancer. It allows tumour cells to become ‘invisible’ and avoid immune attack by antitumour T cells. In tumour harbouring properties of professional antigen presenting cells (i.e. tumour B cells in lymphoma), downregulation/loss of the antigen presentation may also prevent direct priming of naïve T cells by tumour cells. Here, we review treatments that may induce/restore antigen presentation by the tumour cells. These treatments may increase the generation of antitumour T cells and/or their capacity to recognise and eliminate tumour cells. By forcing tumour cells to present their antigens, these treatments may sensitise patients to T cell–based immunotherapies, including checkpoint inhibitors. © 2016 Elsevier Ltd
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01416159
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Wednesday, December 14, 2016 - 10:10:15 AM
Last modification on : Wednesday, October 14, 2020 - 4:10:18 AM

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Marie Charette, Aurélien Marabelle, Roch Houot. Turning tumour cells into antigen presenting cells: The next step to improve cancer immunotherapy?. European Journal of Cancer, Elsevier, 2016, 68, pp.134--147. ⟨10.1016/j.ejca.2016.09.010⟩. ⟨hal-01416159⟩

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