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Journal articles
Turning tumour cells into antigen presenting cells: The next step to improve cancer immunotherapy?
Abstract : Downregulation/loss of the antigen presentation is a major immune escape mechanism in cancer. It allows tumour cells to become ‘invisible’ and avoid immune attack by antitumour T cells. In tumour harbouring properties of professional antigen presenting cells (i.e. tumour B cells in lymphoma), downregulation/loss of the antigen presentation may also prevent direct priming of naïve T cells by tumour cells. Here, we review treatments that may induce/restore antigen presentation by the tumour cells. These treatments may increase the generation of antitumour T cells and/or their capacity to recognise and eliminate tumour cells. By forcing tumour cells to present their antigens, these treatments may sensitise patients to T cell–based immunotherapies, including checkpoint inhibitors. © 2016 Elsevier Ltd
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01416159
Contributor : Xavier Chard-Hutchinson Connect in order to contact the contributor
Submitted on : Wednesday, December 14, 2016 - 10:10:15 AM
Last modification on : Thursday, January 14, 2021 - 11:26:04 AM
Contributor : Xavier Chard-Hutchinson Connect in order to contact the contributor
Submitted on : Wednesday, December 14, 2016 - 10:10:15 AM
Last modification on : Thursday, January 14, 2021 - 11:26:04 AM