Monocopper complex based on N-tripodal ligand immobilized in a Nafion® film for biomimetic detection of catechols: Application to dopamine

M. Boulkroune (1, 2) , Alizée Lemaire (1) , A. Chibani (2) , Florence Geneste (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 UMC - Université Frères Mentouri – Constantine 1 = Constantine 1 – Frères Mentouri University

A complex based on bis-pyrazolyl N-tripodal ligand known to present a good catalytic activity for the oxidation of 3,5-di-tert-butylcatechol is used to prepare a novel biomimetic sensor for the determination of catechol derivatives. The modified electrode prepared by encapsulation of the complex in a Nafion® film leads to an electrochemical signal 4.4 times higher than with a glassy carbon electrode for dopamine detection in pH 7 medium. After optimization of the conditions used to immobilize the catalyst on the electrode surface, a calibration curve was obtained with linearity in the range of 30–320 μmol L−1 and a detection limit of 8 μmol L−1. The sensor was not affected by ascorbic acid and uric acid in similar concentrations to dopamine and its electrochemical response was stable after 40 determinations. The biomimetic sensor can also be used for the detection of other catechol derivatives.

Mots clés: Ligands; Neurophysiology; Organic acids; Amines; Ascorbic acid; Biomimetics; Carbon; Phenols; Electrodes; Curve fitting; Catalytic oxidation; Glass membrane electrodes; Catalyst activity; Electrochemical electrodes; Monocopper complex; Modified electrodes; Dopamine; Catechol; Biomimetic sensors

Domaines: Chimie organique

M. Boulkroune, Alizée Lemaire, A. Chibani, Florence Geneste. Monocopper complex based on N-tripodal ligand immobilized in a Nafion® film for biomimetic detection of catechols: Application to dopamine. Electrochimica Acta, 2016, 221, pp.80--85. ⟨10.1016/j.electacta.2016.10.040⟩. ⟨hal-01416440⟩