Remodeling of adhesion and modulation of mechanical tensile forces during apoptosis in Drosophila epithelium

Abstract : Apoptosis is a mechanism of eliminating damaged or unnecessary cells during development and tissue homeostasis. During apoptosis within a tissue, the adhesions between dying and neighboring non-dying cells need to be remodeled so that the apoptotic cell is expelled. In parallel, contraction of actomyosin cables formed in apoptotic and neighboring cells drives cell extrusion. To date, the coordination between the dynamics of cell adhesion and the progressive changes in tissue tension around an apoptotic cell is not fully understood. Live imaging of histoblast expansion, which is a coordinated tissue replacement process during Drosophila metamorphosis, shows remodeling of adherens junctions (AJs) between apoptotic and non-dying cells, with a reduction in the levels of AJ components, including E-cadherin. Concurrently, surrounding tissue tension is transiently released. Contraction of a supra-cellular actomyosin cable, which forms in neighboring cells, brings neighboring cells together and further reshapes tissue tension toward the completion of extrusion. We propose a model in which modulation of tissue tension represents a mechanism of apoptotic cell extrusion.
Type de document :
Article dans une revue
Development (Cambridge, England), Company of Biologists, 2017, 144 (1), pp.95-105. 〈10.1242/dev.139865〉
Liste complète des métadonnées

Littérature citée [10 références]  Voir  Masquer  Télécharger

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01439358
Contributeur : Laurent Jonchère <>
Soumis le : vendredi 8 septembre 2017 - 10:26:10
Dernière modification le : jeudi 11 janvier 2018 - 06:24:24

Fichier

Remodeling of adhesion and mod...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Xiang Teng, Lei Qin, Roland Le Borgne, Yusuke Toyama. Remodeling of adhesion and modulation of mechanical tensile forces during apoptosis in Drosophila epithelium. Development (Cambridge, England), Company of Biologists, 2017, 144 (1), pp.95-105. 〈10.1242/dev.139865〉. 〈hal-01439358〉

Partager

Métriques

Consultations de la notice

46

Téléchargements de fichiers

13