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Journal Articles Molecular & Cellular Oncology Year : 2016

Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications

Abstract

Loss of Aurora A in Drosophila neuroblasts promotes loss of cell fate, leading to brain tumors. We showed that these tumor stem cells are delayed during mitosis and efficiently segregate their chromosomes even without the spindle assembly checkpoint. Here, we discuss the possible relevance of our results to human cancers.

Dates and versions

hal-01439366 , version 1 (18-01-2017)

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Renaud Caous, Laurent Richard-Parpaillon, Régis Giet. Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications. Molecular & Cellular Oncology, 2016, 3 (3), pp.e1140261. ⟨10.1080/23723556.2016.1140261⟩. ⟨hal-01439366⟩
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