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Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications

Abstract : Loss of Aurora A in Drosophila neuroblasts promotes loss of cell fate, leading to brain tumors. We showed that these tumor stem cells are delayed during mitosis and efficiently segregate their chromosomes even without the spindle assembly checkpoint. Here, we discuss the possible relevance of our results to human cancers.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01439366
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, January 18, 2017 - 3:33:49 PM
Last modification on : Thursday, February 27, 2020 - 5:11:26 PM

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Renaud Caous, Laurent Richard-Parpaillon, Régis Giet. Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications. Molecular & Cellular Oncology, Taylor et Francis, 2016, 3 (3), pp.e1140261. ⟨10.1080/23723556.2016.1140261⟩. ⟨hal-01439366⟩

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