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Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications

Renaud Caous 1 Laurent Richard-Parpaillon 1 Régis Giet 1
1 IGDR - Institut de Génétique et Développement de Rennes
Abstract : Loss of Aurora A in Drosophila neuroblasts promotes loss of cell fate, leading to brain tumors. We showed that these tumor stem cells are delayed during mitosis and efficiently segregate their chromosomes even without the spindle assembly checkpoint. Here, we discuss the possible relevance of our results to human cancers.
Keywords : Spindle Assembly Checkpoint stem cell tumour Aneuploidy Aurora A kinase
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01439366
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, January 18, 2017 - 3:33:49 PM
Last modification on : Thursday, January 14, 2021 - 11:15:58 AM

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IGDR | UNIV-RENNES1 | CNRS | BIOSIT | UR1-UFR-SVE | UNIV-RENNES | UR1-BIO-SA

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Renaud Caous, Laurent Richard-Parpaillon, Régis Giet. Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications. Molecular & Cellular Oncology, Taylor et Francis, 2016, 3 (3), pp.e1140261. ⟨10.1080/23723556.2016.1140261⟩. ⟨hal-01439366⟩

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