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Aurora-A: an expedition to the pole of the spindle in Xenopus egg extracts

Abstract : The aim of this short review is to describe the contribution of Xenopus laevis egg extracts to the discovery and understanding of the regulation and function of the serine/threonine kinase Aurora-A. The power of these extracts to recapitulate cell cycle events makes them a precious tool to decipher complex biological processes at the molecular level, including the mechanisms that affect Aurora-A (post-translational modifications) and mechanisms in which Aurora-A plays a crucial role (bipolar spindle assembly). We focus on the results obtained in cell-free extracts, but we also give an updated overview of Aurora A functions found in other systems.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01439374
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, January 18, 2017 - 3:34:11 PM
Last modification on : Wednesday, May 16, 2018 - 11:23:52 AM

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Jacek Z. Kubiak, Claude Prigent. Aurora-A: an expedition to the pole of the spindle in Xenopus egg extracts. International Journal of Developmental Biology, University of the Basque Country Press, 2016, 60 (7-8-9), pp.255-261. ⟨10.1387/ijdb.160189jk⟩. ⟨hal-01439374⟩

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