S116 Cardiopulmonary bypass induces lymphopenia and decreases lymphocyte proliferation ability: IL-10 and PD-L1 as potential therapeutic targets to reduce postoperative infection

Fabrice Uhel (1, 2) , Mathieu Lesouhaitier (1, 2) , Murielle Gregoire (3, 4, 2) , Baptiste Gaudriot (2) , Arnaud Gacouin (5, 1) , Yves Le Tulzo (5, 1) , Erwan Flecher (6, 3) , Karin Tarte (7, 8) , Jean-Marc Tadié (5, 1)

1 Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
2 CHU Pontchaillou [Rennes]
3 Service de chirurgie thoracique cardiaque et vasculaire [Rennes] = Thoracic and Cardiovascular Surgery [Rennes]
4 MICMAC - Microenvironment, Cell Differentiation, Immunology and Cancer
5 CIC - Centre d'Investigation Clinique [Rennes]
6 LTSI - Laboratoire Traitement du Signal et de l'Image
7 Service d’immunologie, de thérapie cellulaire et d’hématopoïèse
8 MiCa - Microenvironnement et cancer

no abstract

Domains: Life Sciences [q-bio]; Bioengineering

Fabrice Uhel, Mathieu Lesouhaitier, Murielle Gregoire, Baptiste Gaudriot, Arnaud Gacouin, et al.. S116 Cardiopulmonary bypass induces lymphopenia and decreases lymphocyte proliferation ability: IL-10 and PD-L1 as potential therapeutic targets to reduce postoperative infection. Proceedings of Réanimation 2017, the French Intensive Care Society International Congress, 2017, Paris, France. pp.S116, ⟨10.1186/s13613-016-0224-7⟩. ⟨hal-01446564⟩