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Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes

Abstract : Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non-infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity.
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Submitted on : Thursday, December 13, 2018 - 10:15:33 AM
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Legentil et al. - Synthesis an...
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Laurent Legentil, Sorya Belaz, Jean-Pierre Gangneux, Florence Robert-Gangneux, Vincent Ferrières. Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2017, 27 (2), pp.152-155. ⟨10.1016/j.bmcl.2016.11.090⟩. ⟨hal-01446721⟩



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