Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes

Laurent Legentil; Sorya Belaz; Jean-Pierre Gangneux; Florence Robert-Gangneux; Vincent Ferrières

Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes

Laurent Legentil ¹ Sorya Belaz ^{2, 3} Jean-Pierre Gangneux ^{2, 3} Florence Robert-Gangneux ^{3, 2} Vincent Ferrières ^{1, *}

* Corresponding author

1 ISCR - Institut des Sciences Chimiques de Rennes

2 Irset - Institut de recherche, santé, environnement et travail

3 Service de Parasitologie-Mycologie [Rennes]

Abstract : Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non-infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity.

Keywords : Carbohydrates Fluorescence Galactofuranosides Leishmania Macrophages

Document type :

Journal articles

Domain :

Chemical Sciences

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Submitted on : Thursday, December 13, 2018 - 10:15:33 AM
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Legentil et al. - Synthesis an...

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