Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes
Abstract
Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non-infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity.
Domains
Chemical Sciences
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Legentil et al. - Synthesis and biological properties of galactofura.pdf (408.41 Ko)
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