Synthesis of new triphenylphosphines with pending ethynyl substituents

Guillaume Grelaud (1) , Gilles Argouarch (1) , Frédéric Paul (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

The straightforward isolation and characterization of new triphenylphosphines possessing a pendent ethynyl substituent on one or several peripheral aryl ring(s) are reported. The synthesis of this family of compounds is achieved by retro-Favorsky reactions from the corresponding propargylic alcohol derivatives, themselves obtained following a classic Sonogashira-type coupling between the ad hoc bromophenyl phosphines and 2-methylbut-3-yn-2-ol.

Domaines: Chimie

Guillaume Grelaud, Gilles Argouarch, Frédéric Paul. Synthesis of new triphenylphosphines with pending ethynyl substituents. Tetrahedron Letters, 2010, 51, pp.3786-3788. ⟨10.1016/j.tetlet.2010.05.055⟩. ⟨hal-01468976⟩