NMR reassignment of stictic acid isolated from a Sumatran lichen Stereocaulon montagneanum (Stereocaulaceae) with superoxide anion scavenging activities

Friardi Ismed (1) , Françoise Lohézic-Le Dévéhat (2) , Isabelle Rouaud (2) , Solenn Ferron (2) , Amri Bakhtiar (1) , Joël Boustie (2)

1 LBS - Laboratory of Natural Resource of Sumatra
2 ISCR - Institut des Sciences Chimiques de Rennes

The phytochemical study of Stereocaulon montagneanum harvested in Sumatra (Indonesia) led to the isolation of 11 known compounds including two metabolites not previously described in the genus Stereocaulon, peristictic acid (8) and menegazziaic acid (10). The complete 1H and 13C NMR spectral assignments of stictic acid derivatives are reported with some revisions. Five depsidones belonging to the stictic acid chemosyndrome were superoxide anion scavengers as potent as ascorbic acid and with no toxicity on two human cell lines.

Keywords: antioxidant; cytotoxic; lichen; Stereocaulon; stictic acid chemosyndrome

Domains: Chemical Sciences

Friardi Ismed, Françoise Lohézic-Le Dévéhat, Isabelle Rouaud, Solenn Ferron, Amri Bakhtiar, et al.. NMR reassignment of stictic acid isolated from a Sumatran lichen Stereocaulon montagneanum (Stereocaulaceae) with superoxide anion scavenging activities. Zeitschrift fur Naturforschung C, 2017, 72 (1-2), pp.55-62. ⟨10.1515/znc-2016-0148⟩. ⟨hal-01470072⟩