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Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity

Abstract : Palladium-catalyzed cross coupling reactions (Sonogashira-Hagihara, Suzuki-Miyaura, and Heck) coupling and nickel hydride-mediated tandem isomerization aldolisation have been used for the synthesis of three series of δ-valerolactones substituted in positions 3, 4, 5 and 6 of the lactone ring. The 26 kavaïn-like derivatives were tested against three cell lines and five of them exhibited a weak cytotoxic activity.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01470075
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Submitted on : Friday, February 17, 2017 - 9:43:52 AM
Last modification on : Friday, July 10, 2020 - 4:20:21 PM

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Patricia de A. Amaral, Julien Petrignet, Nicolas Gouault, Taciane Agustini, Françoise Lohézic-Le Dévéhat, et al.. Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity. Journal of the Brazilian Chemical Society, Sociedade Brasileira de Química, SBQ, 2009, 20, pp.1687-1697. ⟨10.1590/S0103-50532009000900018⟩. ⟨hal-01470075⟩

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