Synthesis of 1-Amino-1H-Indenes via a Sequential Suzuki-Miyaura Coupling/Petasis Condensation Sequence

Vankudoth Jayaram; Tailor Sridhar; Gangavaram V. M. Sharma; Fabienne Berrée; Bertrand Carboni

doi:10.1021/acs.joc.6b02549

Journal articles

Synthesis of 1-Amino-1H-Indenes via a Sequential Suzuki-Miyaura Coupling/Petasis Condensation Sequence

Vankudoth Jayaram ^{1, 2} Tailor Sridhar ^{1, 2} Gangavaram V. M. Sharma ^{2, 1, *} Fabienne Berrée ³ Bertrand Carboni ^{3, *}

* Corresponding author

1 Organic and Biomolecular Chemistry Division

IICT - CSIR Indian Institute of Chemical Technology

2 IICT - CSIR Indian Institute of Chemical Technology

3 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : An efficient and straightforward synthesis of 1-amino-1H-indenes is reported from 1,2-bis(boronates) via a sequential Suzuki-Miyaura coupling/Petasis cyclization reaction. Starting from the same monoboronic ester intermediates, an intermolecular version of this approach also afforded (Z)-α,β-unsaturated amino esters in moderate to good yields.

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Journal articles

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Chemical Sciences

Chemical Sciences / Organic chemistry

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Synthesis of 1-Amino-1H-Indenes via a Sequential Suzuki-Miyaura Coupling/Petasis Condensation Sequence

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Synthesis of 1-Amino-1H-Indenes via a Sequential Suzuki-Miyaura Coupling/Petasis Condensation Sequence

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