Remotely Controlled Iridium-Catalyzed Asymmetric Hydrogenation of Terminal 1,1-Diaryl Alkenes

Tatiana Besset (1) , Rafael Gramage-Doria (1) , Joost N. H. Reek (1)

1 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam

Working together: The presence of a remote directing group on terminal 1,1-diaryl and 1,1-dialkyl alkenes led to high and unprecedented enantioselectivity in iridium-catalyzed asymmetric hydrogenation (see scheme). This strategy offers efficient synthetic pathways towards valuable enantiomerically enriched 1,1-diaryl and 1,1-dialkyl alkanes. Moreover, the directing group can be further functionalized.

Domaines: Chimie

Tatiana Besset, Rafael Gramage-Doria, Joost N. H. Reek. Remotely Controlled Iridium-Catalyzed Asymmetric Hydrogenation of Terminal 1,1-Diaryl Alkenes. Angewandte Chemie International Edition, 2013, 52, pp.8795 - 8797. ⟨10.1002/anie.201302942⟩. ⟨hal-01472915⟩