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Journal articles
Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics
Tht Nguyen
1
M.-S. Mouksassi
N. Holford
N. Al-Huniti
I. Freedman
A. C. Hooker
J. John
M. O. Karlsson
D. R. Mould
J. J. Pérez Ruixo
E. L. Plan
R. Savic
Jgc Hasselt
B. Weber
C. Zhou
E. Comets
2, 1
F. Mentré
1
F. Mentré 1
Author
1
IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution (Faculté de médecine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18 - France)
- UP13 - Université Paris 13 (France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_S_1137 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- USPC - Université Sorbonne Paris Cité (Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1137 (101, rue de Tolbiac, 75013 Paris - France)
2
CIC - Centre d'Investigation Clinique [Rennes] (Rue Henri Le Guilloux - Pavillon Clémenceau 35033 Rennes Cedex 9 - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- Hôpital Pontchaillou (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC1414 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous tools are available for evaluation of NLMEM, with a particular emphasis on visual assessment. This first basic tutorial focuses on presenting graphical evaluation tools of NLMEM for continuous data. It illustrates graphs for correct or misspecified models, discusses their pros and cons, and recalls the definition of metrics used.
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01484967
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, March 8, 2017 - 9:33:21 AM
Last modification on : Thursday, June 18, 2020 - 9:29:19 AM
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, March 8, 2017 - 9:33:21 AM
Last modification on : Thursday, June 18, 2020 - 9:29:19 AM
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- HAL Id : hal-01484967, version 1
- DOI : 10.1002/psp4.12161
- PUBMED : 27884052
- PUBMEDCENTRAL : PMC5321813
Collections
UNIV-RENNES1 | CIC | UNIV-PARIS7 | CIC203 | UNIV-PARIS13 | BIOSIT | UR1-UFR-SVE | USPC | UNIV-RENNES | IAME | UNIV-PARIS | UP-SANTE
Citation
Tht Nguyen, M.-S. Mouksassi, N. Holford, N. Al-Huniti, I. Freedman, et al.. Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics. CPT: Pharmacometrics and Systems Pharmacology, American Society for Clinical Pharmacology and Therapeutics ; International Society of Pharmacometrics, 2017, 6 (2), pp.87-109. ⟨10.1002/psp4.12161⟩. ⟨hal-01484967⟩
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