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Journal Articles CPT: Pharmacometrics and Systems Pharmacology Year : 2017

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

M.-S. Mouksassi
  • Function : Author
N. Holford
  • Function : Author
N. Al-Huniti
  • Function : Author
I. Freedman
  • Function : Author
A. C. Hooker
  • Function : Author
J. John
  • Function : Author
M. O. Karlsson
  • Function : Author
D. R. Mould
  • Function : Author
J. J. Pérez Ruixo
  • Function : Author
E. L. Plan
  • Function : Author
R. Savic
  • Function : Author
Jgc Van Hasselt
  • Function : Author
B. Weber
  • Function : Author
C. Zhou

Abstract

This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous tools are available for evaluation of NLMEM, with a particular emphasis on visual assessment. This first basic tutorial focuses on presenting graphical evaluation tools of NLMEM for continuous data. It illustrates graphs for correct or misspecified models, discusses their pros and cons, and recalls the definition of metrics used.

Dates and versions

hal-01484967 , version 1 (08-03-2017)

Identifiers

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Tht Nguyen, M.-S. Mouksassi, N. Holford, N. Al-Huniti, I. Freedman, et al.. Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics. CPT: Pharmacometrics and Systems Pharmacology, 2017, 6 (2), pp.87-109. ⟨10.1002/psp4.12161⟩. ⟨hal-01484967⟩
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