Fully enzymatic esterification/transesterification sequence for the preparation of symmetrical and unsymmetrical trehalose diacyl conjugates - Archive ouverte HAL Access content directly
Journal Articles Green Chemistry Year : 2017

Fully enzymatic esterification/transesterification sequence for the preparation of symmetrical and unsymmetrical trehalose diacyl conjugates

Abstract

Monoacyl and diacyl trehalose were synthesized in two steps from trehalose and carboxylic acids. The carboxylic acids were converted first into the corresponding 2,2,2-trifluoroethyl esters through a biocatalyzed esterification. The acyl donor was then transferred to the disaccharide through biocatalyzed transesterification. Thanks to microwave reaction conditions the transesterification proceeded selectively to the monoacyl trehalose or to the diacyl counterparts depending on the sole amount of the acyl donor. These reaction conditions were also applied for the preparation of unsymmetrical diacyl trehalose in a fully enzymatic sequence.
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Dates and versions

hal-01500396 , version 1 (18-07-2017)

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Sunchu Prabhakar, Thomas Vives, Vincent Ferrières, Thierry Benvegnu, Laurent Legentil, et al.. Fully enzymatic esterification/transesterification sequence for the preparation of symmetrical and unsymmetrical trehalose diacyl conjugates. Green Chemistry, 2017, 19 (4), pp.987-995. ⟨10.1039/c6gc02680j⟩. ⟨hal-01500396⟩
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