Synthesis of Novel Fluorinated Benzofurans and Dihydrobenzofurans

Layal Hariss; Kamal H. Bouhadir; Thierry Roisnel; René Grée; Ali Hachem

doi:10.1055/s-0036-1588623

Journal articles

Synthesis of Novel Fluorinated Benzofurans and Dihydrobenzofurans

Layal Hariss ¹ Kamal H. Bouhadir Thierry Roisnel ² René Grée ^{2, *} Ali Hachem ^{1, *}

* Corresponding author

1 LU - Lebanese University [Beirut]

2 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : Starting from easily accessible propargylic fluorides an intramolecular oxa-Michael addition affords, in good yields, new gem-difluorodihydrobenzofurans bearing an electrophilic double bond in position 2. On these intermediates nucleophilic additions and Diels-Alder reactions have been performed affording functionalized fluorinated dihydrobenzofurans. On the other hand, Pd-catalyzed defluorinations give the corresponding fluorine containing benzofurans.

Keywords : fluorine gem-difluoropropargyls benzofurans 2 3-dihydrobenzofurans oxa-michael additions heterocycles

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Journal articles

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Chemical Sciences

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01500399
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Submitted on : Monday, April 3, 2017 - 11:14:35 AM
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Synthesis of Novel Fluorinated Benzofurans and Dihydrobenzofurans

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Synthesis of Novel Fluorinated Benzofurans and Dihydrobenzofurans

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