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Journal Articles SYNLETT Year : 2017

Synthesis of Novel Fluorinated Benzofurans and Dihydrobenzofurans

Kamal H. Bouhadir
  • Function : Author
René Grée
  • Function : Correspondent author
Ali Hachem
  • Function : Correspondent author

Abstract

Starting from easily accessible propargylic fluorides an intramolecular oxa-Michael addition affords, in good yields, new gem-difluorodihydrobenzofurans bearing an electrophilic double bond in position 2. On these intermediates nucleophilic additions and Diels-Alder reactions have been performed affording functionalized fluorinated dihydrobenzofurans. On the other hand, Pd-catalyzed defluorinations give the corresponding fluorine containing benzofurans.
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Dates and versions

hal-01500399 , version 1 (03-04-2017)

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Layal Hariss, Kamal H. Bouhadir, Thierry Roisnel, René Grée, Ali Hachem. Synthesis of Novel Fluorinated Benzofurans and Dihydrobenzofurans. SYNLETT, 2017, 28 (2), pp.195--200. ⟨10.1055/s-0036-1588623⟩. ⟨hal-01500399⟩
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