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Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis

Ewa Borsuk 1 Joanna Jachowicz 1 Malgorzata Kloc 2 Jean-Pierre Tassan 3 Jacek Z. Kubiak 3
1 Warsaw University, Institute of Zoology, Embryology Department, Warsaw, Poland
2 The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA.
3 IGDR - Institut de Génétique et Développement de Rennes
Abstract : Cdc6 is an important player in cell cycle regulation. It is involved in the regulation of both S-phase and M-phase. Its role during oogenesis is crucial for repression of the S-phase between the first and the second meiotic M-phases, and it also regulates, via CDK1 inhibition, the M-phase entry and exit. This is of special importance for the reactivation of the major M-phase-regulating kinase CDK1 (Cyclin-Dependent Kinase 1) in oocytes entering metaphase II of meiosis and in embryo cleavage divisions, in which precise timing allows coordination between cell cycle events and developmental program of the embryo. In this chapter, we discuss the role of Cdc6 protein in oocytes and early embryos.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01502130
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, April 5, 2017 - 10:08:44 AM
Last modification on : Wednesday, May 16, 2018 - 11:23:52 AM

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UNIV-RENNES1 | IGDR | CNRS | BIOSIT | UR1-UFR-SVE | UNIV-RENNES

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Ewa Borsuk, Joanna Jachowicz, Malgorzata Kloc, Jean-Pierre Tassan, Jacek Z. Kubiak. Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis. Results and Problems in Cell Differentiation, Springer-verlag Berlin Heidelberg, 2017, 59, pp.201-211. ⟨10.1007/978-3-319-44820-6_7⟩. ⟨hal-01502130⟩

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