Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting, Molecular Cell, vol.53, issue.6, pp.1031-1043, 2014. ,
DOI : 10.1016/j.molcel.2014.02.013
The complexity of miRNA-mediated repression, Cell Death and Differentiation, vol.700, issue.1, pp.22-33, 2015. ,
DOI : 10.1126/science.1149460
Widespread changes in protein synthesis induced by microRNAs, Nature, vol.4, issue.7209, pp.58-63, 2008. ,
DOI : 10.1074/mcp.M500241-MCP200
URL : http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:bvb:12-bsb00085066-2
mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues, Molecular Cell, vol.56, issue.1, pp.104-115, 2014. ,
DOI : 10.1016/j.molcel.2014.08.028
The impact of microRNAs on protein output, Nature, vol.35, issue.7209, pp.64-71, 2008. ,
DOI : 10.1101/gr.229202. Article published online before March 2002
The Functions of MicroRNAs: mRNA Decay and Translational Repression, Trends in Cell Biology, vol.25, issue.11, pp.651-665, 2015. ,
DOI : 10.1016/j.tcb.2015.07.011
miRBase: annotating high confidence microRNAs using deep sequencing data, Nucleic Acids Research, vol.42, issue.D1, 2014. ,
DOI : 10.1093/nar/gkt1181
URL : https://academic.oup.com/nar/article-pdf/42/D1/D68/3618976/gkt1181.pdf
A Resource for the Conditional Ablation of microRNAs in the Mouse, Cell Rep, vol.1, 2012. ,
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability, PLoS Genet, vol.3, pp.2395-2403, 2007. ,
DOI : 10.1371/journal.pgen.0030215.eor
URL : http://doi.org/10.1371/journal.pgen.0030215.eor
Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability, Current Biology, vol.20, issue.4, 2010. ,
DOI : 10.1016/j.cub.2009.12.051
The functional scope of plant microRNA-mediated silencing, Trends in Plant Science, vol.19, issue.12, pp.750-756, 2014. ,
DOI : 10.1016/j.tplants.2014.08.006
Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting, Molecular Cell, vol.48, issue.5, pp.760-70, 2012. ,
DOI : 10.1016/j.molcel.2012.10.002
URL : http://doi.org/10.1016/j.molcel.2012.10.002
MicroRNAs in cancer, Annu. Rev. Pathol, vol.9, pp.287-314, 2014. ,
Target mimicry provides a new mechanism for regulation of microRNA activity, Nature Genetics, vol.17, issue.8, pp.1033-103710, 1038. ,
DOI : 10.1038/ng2079
Redefining MicroRNA Targets, Current Biology, vol.19, issue.10, 2009. ,
DOI : 10.1016/j.cub.2009.03.059
URL : https://hal.archives-ouvertes.fr/hal-00611806
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?, Cell, vol.146, issue.3, 2011. ,
DOI : 10.1016/j.cell.2011.07.014
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells, Nature Methods, vol.18, issue.9, pp.721-727, 1079. ,
DOI : 10.1038/nmeth1079
Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition, Molecular Cell, vol.56, issue.3, 2014. ,
DOI : 10.1016/j.molcel.2014.09.018
URL : http://doi.org/10.1016/j.molcel.2014.09.018
Inhibiting plant microRNA activity: molecular SPONGEs, target MIMICs and STTMs all display variable efficacies against target microRNAs, Plant Biotechnol. J, pp.13-915, 2015. ,
DOI : 10.1111/pbi.12327
Activation of gene expression by small RNA, Current Opinion in Microbiology, vol.12, issue.6, pp.674-682, 2009. ,
DOI : 10.1016/j.mib.2009.09.009
A 3??? External Transcribed Spacer in a tRNA Transcript Acts as a Sponge for Small RNAs to Prevent Transcriptional Noise, Molecular Cell, vol.58, issue.3, pp.393-405, 2015. ,
DOI : 10.1016/j.molcel.2015.03.013
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology, Nature, vol.33, issue.7301, pp.1033-1038, 2010. ,
DOI : 10.4161/cc.7.18.6734
Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs, Cell, vol.147, issue.2, pp.344-357, 2011. ,
DOI : 10.1016/j.cell.2011.09.029
In??Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma, Cell, vol.147, issue.2, pp.382-395, 2011. ,
DOI : 10.1016/j.cell.2011.09.032
Circular RNAs are a large class of animal RNAs with regulatory potency, Nature, vol.40, issue.7441, pp.333-341, 2013. ,
DOI : 10.1093/nar/gkr688
Natural RNA circles function as efficient microRNA sponges, Nature, vol.175, issue.7441, pp.495-384, 2013. ,
DOI : 10.1007/s00221-006-0526-3
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs, Nature Communications, vol.7 ,
DOI : 10.1371/journal.pgen.1002363
URL : http://www.nature.com/articles/ncomms11215.pdf
Competition between target sites of regulators shapes post-transcriptional gene regulation, Nature Reviews Genetics, vol.768, issue.2, pp.113-139, 2015. ,
DOI : 10.1101/gad.182758.111
Functional Interplay between RNA-Binding Protein HuR and microRNAs, Current Protein & Peptide Science, vol.13, issue.4, pp.372-379, 2012. ,
DOI : 10.2174/138920312801619394
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535178/pdf
miRNA???target chimeras reveal miRNA 3???-end pairing as a major determinant of Argonaute target specificity, Nature Communications, vol.5 ,
DOI : 10.1038/ncomms3977
A tale of two sequences: microRNA-target chimeric reads, Genetics Selection Evolution, vol.6, issue.1 ,
DOI : 10.1038/ncomms9864
URL : https://hal.archives-ouvertes.fr/hal-01341365
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding, Cell, vol.153, issue.3, 2013. ,
DOI : 10.1016/j.cell.2013.03.043
URL : http://doi.org/10.1016/j.cell.2013.03.043
miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19???miR-106a interaction, Nature Chemical Biology, vol.732, issue.2, pp.107-121, 2015. ,
DOI : 10.1038/nsmb.2115
Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR, Molecular Cell, vol.43, issue.3, pp.340-352, 2011. ,
DOI : 10.1016/j.molcel.2011.06.008
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing, Molecular Cell, vol.27, issue.1, pp.91-105, 2007. ,
DOI : 10.1016/j.molcel.2007.06.017
URL : http://doi.org/10.1016/j.molcel.2007.06.017
Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs, Genome Biology, vol.15, issue.3, 2014. ,
DOI : 10.1073/pnas.0811466106
URL : https://genomebiology.biomedcentral.com/track/pdf/10.1186/gb-2014-15-3-r51?site=genomebiology.biomedcentral.com
An alternative mode of microRNA target recognition, Nature Structural & Molecular Biology, vol.2, issue.3, pp.321-328, 2012. ,
DOI : 10.1016/S0092-8674(01)00568-2
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541676
A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets, Nature Methods, vol.460, issue.3, pp.253-258, 2013. ,
DOI : 10.1198/016214504000000683
Unambiguous Identification of miRNA:Target Site Interactions by Different Types of Ligation Reactions, Molecular Cell, vol.54, issue.6, pp.1042-1054, 2014. ,
DOI : 10.1016/j.molcel.2014.03.049
Endogenous microRNA sponges: evidence and controversy, Nature Reviews Genetics, vol.4, issue.5, 2016. ,
DOI : 10.1016/j.molcel.2015.11.014
The multilayered complexity of ceRNA crosstalk and competition, Nature, vol.498, issue.7483, pp.344-52, 2014. ,
DOI : 10.1038/nature12132
MIROR: a method for cell-type specific microRNA occupancy rate prediction, Mol. BioSyst., vol.19, issue.suppl, pp.1377-84, 2014. ,
DOI : 10.1038/nsmb.2214
Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance, Molecular Cell, vol.54, issue.5, pp.766-776, 2014. ,
DOI : 10.1016/j.molcel.2014.03.045
Identification of a target RNA motif for RNA-binding protein HuR, Proceedings of the National Academy of Sciences, vol.278, issue.38, pp.2987-2992, 2004. ,
DOI : 10.1074/jbc.M302547200
Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability, Molecular Cell, vol.43, issue.3, pp.327-339, 2011. ,
DOI : 10.1016/j.molcel.2011.06.007
URL : http://doi.org/10.1016/j.molcel.2011.06.007
sponges RNA-binding protein HuR, Nucleic Acids Research, vol.44, issue.5, pp.2378-2392, 2016. ,
DOI : 10.1093/nar/gkw017
URL : https://academic.oup.com/nar/article-pdf/44/5/2378/17438174/gkw017.pdf
Ule, iCLIP--transcriptome-wide mapping of protein-RNA interactions with individual nucleotide resolution, J. Vis. Exp, pp.1-7, 2011. ,
DOI : 10.3791/2638
URL : https://www.jove.com/pdf/2638/iclip-transcriptome-wide-mapping-protein-rna-interactions-with
Ule, iCLIP: protein-RNA interactions at nucleotide resolution, pp.65-274, 2014. ,
DOI : 10.1016/j.ymeth.2013.10.011
URL : http://doi.org/10.1016/j.ymeth.2013.10.011
Emerging Roles for Natural MicroRNA Sponges, Current Biology, vol.20, issue.19, pp.858-861, 2010. ,
DOI : 10.1016/j.cub.2010.08.052
URL : http://doi.org/10.1016/j.cub.2010.08.052
MicroRNA sponges: Progress and possibilities, RNA, vol.16, issue.11 ,
DOI : 10.1261/rna.2414110
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957044
THE MIR-15A/MIR-16-1 CLUSTER CONTROLS PROSTATE CANCER PROGRESSION CONTROL BY TARGETING OF MULTIPLE ONCOGENIC ACTIVITIES, The Journal of Urology, vol.181, issue.4, pp.1271-1277, 2008. ,
DOI : 10.1016/S0022-5347(09)60542-5
Plant and animal microRNAs: similarities and differences, Functional & Integrative Genomics, vol.100, issue.3, pp.129-135, 2005. ,
DOI : 10.1007/s10142-005-0145-2
MicroRNAs can generate thresholds in target gene expression, Nature Genetics, vol.43, issue.9, pp.854-859, 2011. ,
DOI : 10.1126/science.1137999
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163764
Small RNAs establish gene expression thresholds, Current Opinion in Microbiology, vol.11, issue.6, pp.574-583, 2008. ,
DOI : 10.1016/j.mib.2008.09.016
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613760
Molecular Titration and Ultrasensitivity in Regulatory Networks, Journal of Molecular Biology, vol.384, issue.5, pp.1106-1125, 2008. ,
DOI : 10.1016/j.jmb.2008.09.079
The Transcription Factor Titration Effect Dictates Level of Gene Expression, Cell, vol.156, issue.6, pp.1312-1335, 2014. ,
DOI : 10.1016/j.cell.2014.02.022
CeRNA cross-talk in cancer: When ce-bling rivalries go awry, Cancer Discov ,
DOI : 10.1158/2159-8290.cd-13-0202
URL : http://cancerdiscovery.aacrjournals.org/content/candisc/3/10/1113.full.pdf
Competitive Endogenous RNAs Cannot Alter MicroRNA Function In??Vivo, Molecular Cell, vol.54, issue.5, pp.711-713, 2014. ,
DOI : 10.1016/j.molcel.2014.05.023
URL : http://doi.org/10.1016/j.molcel.2014.05.023
On the art of identifying effective and specific siRNAs, Nature Methods, vol.7, issue.9, pp.670-676, 2006. ,
DOI : 10.4161/cc.3.6.892
Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA, Science, vol.106, issue.32, pp.1563-1566, 2010. ,
DOI : 10.1073/pnas.0900210106
Hepatitis C Virus RNA Functionally Sequesters miR-122, Cell, vol.160, issue.6, pp.160-2015 ,
DOI : 10.1016/j.cell.2015.02.025
URL : http://doi.org/10.1016/j.cell.2015.02.025
Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication, Proceedings of the National Academy of Sciences, vol.275, issue.1, pp.1881-1887, 2013. ,
DOI : 10.1016/S0076-6879(96)75005-X
Competitive virus and host RNAs: the interplay of a hidden virus and host interaction, Protein & Cell, vol.4, issue.Suppl 2, pp.348-356, 2014. ,
DOI : 10.3389/fgene.2013.00202
The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo ,
Circular RNA and miR-7 in Cancer, Cancer Research, vol.73, issue.18, 2013. ,
DOI : 10.1158/0008-5472.CAN-13-1568
URL : http://cancerres.aacrjournals.org/content/canres/73/18/5609.full.pdf
Systematic exploration of autonomous modules in noisy microRNA-target networks for testing the generality of the ceRNA hypothesis, BMC Genomics, vol.15, issue.1, pp.1178-1188, 2014. ,
DOI : 10.1145/1656274.1656278
Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks, Genome Research, vol.25, issue.2, pp.257-67, 2015. ,
DOI : 10.1101/gr.178194.114
URL : http://genome.cshlp.org/content/25/2/257.full.pdf
Integrative analyses reveal a long noncoding RNAmediated sponge regulatory network in prostate cancer, Nat. Commun, vol.7 ,
DOI : 10.1038/ncomms10982
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796315
Identification and consequences of miRNA???target interactions ??? beyond repression of gene expression, Nature Reviews Genetics, vol.8, issue.9, pp.599-612, 2014. ,
DOI : 10.1126/science.1215704
Quantifying the strength of miRNA???target interactions, Methods, vol.85, p.85, 2015. ,
DOI : 10.1016/j.ymeth.2015.04.012
Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation, Science, vol.35, issue.7, pp.318-1931, 2007. ,
DOI : 10.1093/nar/gkm133
Expanded identification and characterization of mammalian circular RNAs, Genome Biology, vol.19, issue.7, 2014. ,
DOI : 10.1101/gr.073585.107
Potent degradation of neuronal miRNAs induced by highly complementary targets, EMBO reports, vol.16, issue.4, pp.500-511, 2015. ,
DOI : 10.15252/embr.201540078
Identification of factors involved in target RNA-directed microRNA degradation, Nucleic Acids Research, vol.44, issue.6, pp.2873-87, 2016. ,
DOI : 10.1093/nar/gkw040
Regulatory RNAs in Bacteria, Cell, vol.136, issue.4, pp.615-628, 2009. ,
DOI : 10.1016/j.cell.2009.01.043
URL : http://doi.org/10.1016/j.cell.2009.01.043
Small RNAs in Bacteria and Archaea, 2015. ,
DOI : 10.1016/bs.adgen.2015.05.001
A conserved small RNA promotes silencing of the outer membrane protein YbfM, Molecular Microbiology, vol.9, issue.3, 2009. ,
DOI : 10.1111/j.1365-2958.2009.06688.x
Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target, Genes & Development, vol.23, issue.17, pp.2004-2015, 2009. ,
DOI : 10.1101/gad.541609
URL : http://genesdev.cshlp.org/content/23/17/2004.full.pdf
Switching off small RNA regulation with trap-mRNA, Molecular Microbiology, vol.9, issue.5, 2009. ,
DOI : 10.1111/j.1365-2958.2009.06807.x
Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA, The EMBO Journal, vol.34, issue.11, pp.1478-1492, 2015. ,
DOI : 10.15252/embj.201490546
Identification of Bacteriophage-Encoded Anti-sRNAs in Pathogenic Escherichia coli, Molecular Cell, vol.55, issue.2, 2014. ,
DOI : 10.1016/j.molcel.2014.05.006
Modelling Competing Endogenous RNA Networks, PLoS ONE, vol.5, issue.7 ,
DOI : 10.1371/journal.pone.0066609.s001
URL : http://doi.org/10.1371/journal.pone.0066609
Global Mapping of Small RNA-Target Interactions in Bacteria, Molecular Cell, vol.63, issue.5, pp.884-97, 2016. ,
DOI : 10.1016/j.molcel.2016.07.026
Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics, Journal of Hematology & Oncology, vol.281, issue.Database issue, 2015. ,
DOI : 10.1111/febs.12880
URL : https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-015-0129-1?site=jhoonline.biomedcentral.com
Long Noncoding RNAs in Cancer Pathways, Cancer Cell, vol.29, issue.4, pp.452-63, 2016. ,
DOI : 10.1016/j.ccell.2016.03.010
URL : http://doi.org/10.1016/j.ccell.2016.03.010
Probing sequence-specific RNA recognition by the bacteriophage MS2 coat protien, Nucleic Acids Research, vol.23, issue.13, pp.2512-2518, 1995. ,
DOI : 10.1093/nar/23.13.2512
URL : https://academic.oup.com/nar/article-pdf/23/13/2512/7123169/23-13-2512.pdf
Competitive Regulation of Nucleolin Expression by HuR and miR-494, Molecular and Cellular Biology, vol.31, issue.20, pp.4219-4231, 2011. ,
DOI : 10.1128/MCB.05955-11
MS2-TRAP (MS2-tagged RNA affinity purification): Tagging RNA to identify associated miRNAs, Methods, vol.58, issue.2, pp.58-81, 2012. ,
DOI : 10.1016/j.ymeth.2012.07.004
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493847
Use of Aptamer Tagging to Identify In Vivo Protein Binding Partners of Small Regulatory RNAs, Methods Mol. Biol, vol.905, pp.177-200, 2012. ,
DOI : 10.1007/978-1-61779-949-5_11
A game of tag: MAPS catches up on RNA interactomes, RNA Biology, vol.15, issue.5, 2016. ,
DOI : 10.1016/j.gdata.2015.05.033
Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study, Nat. Methods, vol.11, pp.809-815, 2014. ,
RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites, Cell, vol.159, issue.1, pp.188-199, 2014. ,
DOI : 10.1016/j.cell.2014.08.018
Fast and effective prediction of microRNA/target duplexes, RNA, vol.10, issue.10, pp.1507-1524, 2004. ,
DOI : 10.1261/rna.5248604
Argonaute HITS-CLIP decodes microRNA???mRNA interaction maps, Nature, vol.318, pp.479-86, 2009. ,
DOI : 10.4161/rna.4.2.4640
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733940
Seq and CLIP through the miRNA world, Genome Biology, vol.15, issue.1 ,
DOI : 10.1186/gb4151
URL : https://genomebiology.biomedcentral.com/track/pdf/10.1186/gb4151?site=genomebiology.biomedcentral.com
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP, Cell, vol.141, issue.1, pp.141-129, 2010. ,
DOI : 10.1016/j.cell.2010.03.009
URL : http://doi.org/10.1016/j.cell.2010.03.009
CLIP: viewing the RNA world from an RNA-protein interactome perspective, Science China Life Sciences, vol.40, issue.Suppl, pp.75-88, 2015. ,
DOI : 10.1093/nar/gks148
URL : https://link.springer.com/content/pdf/10.1007%2Fs11427-014-4764-5.pdf
Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq, Methods Mol. Biol, pp.211-228, 2016. ,
DOI : 10.1007/978-1-4939-3067-8_13
An Improved Method for Surface Immobilisation of RNA: Application to Small Non-Coding RNA - mRNA Pairing, PLoS ONE, vol.65, issue.11 ,
DOI : 10.1371/journal.pone.0079142.s001
High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries, Nature Methods, vol.442, issue.8, pp.840-846, 2012. ,
DOI : 10.1128/JVI.05843-11
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518396
MiRonTop: mining microRNAs targets across large scale gene expression studies, Bioinformatics, vol.26, issue.24, pp.3131-3132, 2010. ,
DOI : 10.1093/bioinformatics/btq589
URL : https://hal.archives-ouvertes.fr/hal-00585329
Target activation by regulatory RNAs in bacteria, FEMS Microbiology Reviews, vol.39, issue.3, 2015. ,
DOI : 10.1093/femsre/fuv016
URL : https://academic.oup.com/femsre/article-pdf/39/3/362/10741263/fuv016.pdf
Development and Applications of CRISPR-Cas9 for Genome Engineering, Cell, vol.157, issue.6, 2014. ,
DOI : 10.1016/j.cell.2014.05.010
Genomescale transcriptional activation by an engineered CRISPR-Cas9 complex, Nature, pp.517-583, 1038. ,
DOI : 10.1038/nature14136
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420636
RNA-Based Therapeutics: Current Progress and Future Prospects, Chemistry & Biology, vol.19, issue.1, pp.60-71, 2012. ,
DOI : 10.1016/j.chembiol.2011.12.008
URL : http://doi.org/10.1016/j.chembiol.2011.12.008
Toxicology of antisense therapeutics, Toxicology and Applied Pharmacology, vol.201, issue.1, pp.66-83, 2004. ,
DOI : 10.1016/j.taap.2004.04.017
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform, Annual Review of Pharmacology and Toxicology, vol.50, issue.1, 2010. ,
DOI : 10.1146/annurev.pharmtox.010909.105654
Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA, Chemistry & Biology, vol.8, issue.1, pp.1-7, 2001. ,
DOI : 10.1016/S1074-5521(00)00058-2
LNA: a versatile tool for therapeutics and genomics, Trends in Biotechnology, vol.21, issue.2, pp.74-81, 2003. ,
DOI : 10.1016/S0167-7799(02)00038-0
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals, Nucleic Acids Research, vol.35, issue.2, pp.687-700, 2007. ,
DOI : 10.1093/nar/gkl1071
URL : https://academic.oup.com/nar/article-pdf/35/2/687/16757619/gkl1071.pdf
LNA-mediated microRNA silencing in non-human primates, Nature, vol.120, issue.7189, pp.452-896, 2008. ,
DOI : 10.1038/nature06783
In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides, Nucleic Acids Research, vol.31, issue.3, pp.31-953, 2003. ,
DOI : 10.1093/nar/gkg185
an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial, Lancet, vol.375, issue.10, pp.998-1006, 2010. ,
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids, Proceedings of the National Academy of Sciences, vol.258, issue.1-2, pp.5633-5638, 2000. ,
DOI : 10.1016/0014-2999(94)90072-8
URL : http://www.pnas.org/content/97/10/5633.full.pdf
Chemical modification study of antisense gapmers., Nucleic Acid Ther, pp.344-59, 2012. ,
Towards a therapy for Angelman syndrome by targeting a long non-coding RNA, Nature, vol.77, issue.7539, p.10, 1038. ,
DOI : 10.1073/pnas.1318835110
Exon-skipping therapy for Duchenne muscular dystrophy, The Lancet, vol.378, issue.9791, pp.546-547, 2011. ,
DOI : 10.1016/S0140-6736(11)61028-3
Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4, Nat. Commun, vol.7 ,
A microRNA switch regulates the rise in hypothalamic GnRH production before puberty, Nature Neuroscience, vol.28, issue.6, pp.835-879, 2016. ,
DOI : 10.1038/nprot.2008.73
miR-34: from bench to bedside, Oncotarget, vol.5, issue.4, pp.872-81, 2014. ,
DOI : 10.18632/oncotarget.1825
URL : http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=1825&path%5B%5D=2244
Abstract CT327: Multicenter phase I study of MRX34, a first-in-class microRNA miR-34 mimic liposomal injection, Cancer Research, vol.74, issue.19 Supplement, pp.327-32710, 2014. ,
DOI : 10.1158/1538-7445.AM2014-CT327
Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients, Antiviral Research, vol.111, pp.53-59, 2014. ,
DOI : 10.1016/j.antiviral.2014.08.015
Treatment of HCV Infection by Targeting MicroRNA, New England Journal of Medicine, vol.368, issue.18, pp.1685-169410, 1056. ,
DOI : 10.1056/NEJMoa1209026
LNA-mediated anti-miR-155 silencing in lowgrade B-cell lymphomas, Blood, vol.120, pp.1678-1686, 2012. ,