Skip to Main content Skip to Navigation
Journal articles

Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities

Abstract : Cells reproduce using two types of divisions: mitosis, which generates two daughter cells each with the same genomic content as the mother cell, and meiosis, which reduces the number of chromosomes of the parent cell by half and gives rise to four gametes. The mechanisms that promote the proper progression of the mitotic and meiotic cycles are highly conserved and controlled. They require the activities of two types of serine-threonine kinases, the cyclin-dependent kinases (CDKs) and the Dbf4-dependent kinase (DDK). CDK and DDK are essential for genome duplication and maintenance in both mitotic and meiotic divisions. In this review, we aim to highlight how these kinases cooperate to orchestrate diverse processes during cellular reproduction, focusing on meiosis-specific adaptions of their regulation and functions in DNA metabolism.
Document type :
Journal articles
Complete list of metadatas

Cited literature [121 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01502136
Contributor : Laurent Jonchère <>
Submitted on : Thursday, May 3, 2018 - 3:35:45 PM
Last modification on : Thursday, February 27, 2020 - 4:32:54 PM

File

genes-08-00105-v2.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Blanca Gomez-Escoda, Pei-Yun Jenny Wu. Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities. Genes, MDPI, 2017, Results and Problems in Cell Differentiation, 8 (3), pp.201-211. ⟨10.3390/genes8030105⟩. ⟨hal-01502136⟩

Share

Metrics

Record views

192

Files downloads

250