Outcomes of intra-detrusor injections of botulinum toxin in patients with spina bifida: A systematic review

Juliette Hascoet 1 Andréa Manunta 2 Charlène Brochard 3, 4, 5 Alexis Arnaud 1 Mireille Damphousse 1 Hélène Ménard 1 Jacques Kerdraon 6 Hubert Journel 1 Isabelle Bonan 7, 1, 8 Sylvie Odent 9 Benjamin Fremond 1 Laurent Siproudhis 4, 5, 3 Xavier Gamé 10 Benoit Peyronnet 2, 3, 4
1 CHU Pontchaillou [Rennes]
2 Service d'urologie
3 CIC - Centre d'Investigation Clinique [Rennes]
4 Foie, métabolismes et cancer
5 Service des Maladies de l'Appareil Digestif
6 Centre mutualiste de Kerpape
7 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U1228, Inria Rennes – Bretagne Atlantique , IRISA_D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
8 M2S - Laboratoire Mouvement Sport Santé
9 Service de génétique clinique [Rennes]
10 Service d'Urologie - Transplantation Rénale - Andrologie
Abstract : CONTEXT: Bladder management in spina bifida patients relies on clean intermittent catheterization and oral antimuscarinics with a significant failure rate. The efficacy of intradetrusor injections of botulinum toxin has been confirmed in patients with spinal cord injury or multiple sclerosis but not in patients with myelomeningocele. OBJECTIVE: To conduct a systematic review of current evidence regarding the efficacy of intra-detrusor injections of Botulinum Toxin A (BTX-A) in spina bifida patients with neurogenic detrusor overactivity (NDO) refractory to antimuscarinics. METHODS: A research has been conducted on Medline and Embase using the keywords: ("spina bifida" OR "myelomeningocele" OR "dysraphism") AND "toxin." The search strategy and studies selection were performed using the PICOS method according to the PRISMA statement. RESULT: Twelve published series were included (n = 293 patients). All patients were <18 years old. There was no randomized study comparing BTX-A versus placebo and most studies had no control group. Most studies reported a clinical and urodynamic improvement with resolution of incontinence in 32-100% of patients, a decrease in maximum detrusor pressure from 32 to 54%, an increase of maximum cystometric capacity from 27 to 162%, and an improvement in bladder compliance of 28-176%. Two studies suggested lower efficacy in patients with low compliance bladder compared to those with isolated detrusor overactivity. CONCLUSION: Intradetrusor injections of BTX-A could be effective in children with spina bifida but this assumption is not supported by high level of evidence studies. There is no data available in adult patients. Neurourol. Urodynam. 36:557-564, 2017. © 2016 Wiley Periodicals, Inc.
Keywords : neurogenic bladder Spina bifida spinal dysraphism Botulinum toxin myelomeningocele Detrusor overactivity
Type de document :
Article dans une revue
Neurourology and Urodynamics, Wiley, 2017, 36 (3), pp.557-564. 〈10.1002/nau.23025〉
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01502530
Contributeur : Laurent Jonchère <>
Soumis le : mercredi 5 avril 2017 - 16:27:34
Dernière modification le : lundi 4 mars 2019 - 14:07:58

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UNIV-RENNES1 | CIC | ENS-CACHAN | CIC203 | BIOSIT | UR1-UFR-SVE | UNIV-BREST | NUMECAN | NUMECAN-EXPRES | UNIV-PARIS-SACLAY | IRISA | INRIA2017 | INRIA | UR1-UFR-ISTIC | M2S | UNIV-RENNES2 | UR2-HB | UNIV-RENNES | CENTRALESUPELEC

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Juliette Hascoet, Andréa Manunta, Charlène Brochard, Alexis Arnaud, Mireille Damphousse, et al.. Outcomes of intra-detrusor injections of botulinum toxin in patients with spina bifida: A systematic review. Neurourology and Urodynamics, Wiley, 2017, 36 (3), pp.557-564. 〈10.1002/nau.23025〉. 〈hal-01502530〉

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