Frontispiece: Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light
Abstract
Complexes for Photodynamic Therapy In their Communication on page 234 ff., J. A. Weinstein, H. E. Bryant et al. present two low-molecular-weight, long-lived and photo-stable iridium complexes of the [Ir(N C)2(N N)]+ family which have high two-photon absorption and localise to mitochondria and lysosomal structures. Both are efficient photosensitizers (PS) under 1-photon irradiation resulting in apoptotic death in cancer cell lines at low light doses, low concentrations, and high photo-indices. Complex 1 also displays high PS activity under NIR two-photon excitation, which along with its photo-stability indicates potential future clinical application.