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Frontispiece: Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light

Abstract : Complexes for Photodynamic Therapy In their Communication on page 234 ff., J. A. Weinstein, H. E. Bryant et al. present two low-molecular-weight, long-lived and photo-stable iridium complexes of the [Ir(N C)2(N N)]+ family which have high two-photon absorption and localise to mitochondria and lysosomal structures. Both are efficient photosensitizers (PS) under 1-photon irradiation resulting in apoptotic death in cancer cell lines at low light doses, low concentrations, and high photo-indices. Complex 1 also displays high PS activity under NIR two-photon excitation, which along with its photo-stability indicates potential future clinical application.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01515151
Contributor : Laurent Jonchère <>
Submitted on : Thursday, April 27, 2017 - 9:46:02 AM
Last modification on : Thursday, March 5, 2020 - 2:01:51 PM

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L.K. Mckenzie, I.V. Sazanovich, E. Baggaley, Michel Bonneau, V. Guerchais, et al.. Frontispiece: Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light. Chemistry - A European Journal, Wiley-VCH Verlag, 2017, 23 (2), pp.234--. ⟨10.1002/chem.201780262⟩. ⟨hal-01515151⟩

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