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A novel action of follicle-stimulating hormone in the ovary promotes estradiol production without inducing excessive follicular growth before puberty

Charlotte M. François 1 Florence Petit 1 Frank Giton 2 Alain Gougeon 3 Célia Ravel 4 Solange Magre 1 Joëlle Cohen-Tannoudji 5, 1 Celine J. Guigon 6, 1
1 PAG U1133 - Physiologie de l'Axe Gonadotrope
BFA (UMR_8251 / U1133) - Unité de Biologie Fonctionnelle et Adaptative
3 Equipe 4
Tumeurs endocrines digestives : mécanismes de la tumorigenèse et de la progression tumorale, UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
Abstract : In cyclic females, FSH stimulates ovarian estradiol (E2) production and follicular growth up to the terminal stage. A transient elevation in circulating FSH and E2 levels occurs shortly after birth. But what could be the action of FSH on the ovary during this period, and in particular how it stimulates ovarian steroidogenesis without supporting terminal follicular maturation is intriguing. By experimentally manipulating FSH levels, we demonstrate in mice that the mid-infantile elevation in FSH is mandatory for E2 production by the immature ovary, but that it does not stimulate follicle growth. Importantly, FSH increases aromatase expression to stimulate E2 synthesis, however it becomes unable to induce cyclin D2, a major driver of granulosa cell proliferation. Besides, although FSH prematurely induces luteinizing hormone (LH) receptor expression in granulosa cells, LH pathway is not functional in these cells to induce their terminal differentiation. In line with these results, supplying infantile mice with a superovulation regimen exacerbates E2 production, but it does not stimulate the growth of follicles and it does not induce ovulation. Overall, our findings unveil a regulation whereby high postnatal FSH concentrations ensure the supply of E2 required for programming adult reproductive function without inducing follicular maturation before puberty.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01516023
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Submitted on : Friday, April 28, 2017 - 3:17:57 PM
Last modification on : Tuesday, August 18, 2020 - 2:40:04 PM

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Charlotte M. François, Florence Petit, Frank Giton, Alain Gougeon, Célia Ravel, et al.. A novel action of follicle-stimulating hormone in the ovary promotes estradiol production without inducing excessive follicular growth before puberty. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.46222. ⟨10.1038/srep46222⟩. ⟨hal-01516023⟩

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