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Expression and prognostic value of the cell polarity PAR complex members in thyroid cancer

Abstract : Establishment and maintenance of the apical basal cell polarity, required for proper replication, migration, specialized functions and tissue morphogenesis, relies on three evolutionary conserved complexes: PAR, CRUMBS and SCRIBBLE. Loss of cell polarity/cohesiveness (LOP/C) is implicated in cancer progression, and members of the polarity complex have been described as either oncogenes or oncosuppressors. However, no information on their role in thyroid cancer (TC) progression is available. In the present study, we evaluated the gene expression of the PAR complex members aPKCt, PARD3 alpha/beta and PARD6 alpha/beta/gamma in 95 papillary TC (PTC), compared to their normal matched tissues and in 12 anaplastic TC (ATC). The mRNA and protein levels of investigated genes were altered in the majority of PTC and ATC tissues. In PTC, univariate analysis showed that reduced expression of aPKCt, PARD3 beta and PARD6 gamma mRNAs is associated with increased tumor size, and the reduced expression of PARD3 beta mRNA is associated also with recurrences. Multivariate analysis demonstrated that the presence of lymph node metastasis at diagnosis and the reduced expression of PARD3 beta are independent risk factors for recurrences, with hazard ratio, respectively, of 8.21 (P=0.006) and 3.04 (P=0.029). The latter result was confirmed by the Kaplan-Meier analysis, which evidenced the association between decreased PARD3 beta mRNA levels and shorter disease-free interval. In conclusion, we demonstrated that the expression of PAR complex components is deregulated in the majority of PTC and there is a general trend towards their reduction in ATC tissues. Moreover, a prognostic value for the PARD3 beta gene in PTCs is suggested.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01517821
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, May 3, 2017 - 4:38:25 PM
Last modification on : Tuesday, August 20, 2019 - 3:30:05 PM

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Chiara Tuccilli, Enke Baldini, Yannick Arlot-Bonnemains, Frank Chesnel, Salvatore Sorrenti, et al.. Expression and prognostic value of the cell polarity PAR complex members in thyroid cancer. International Journal of Oncology, Spandidos Publications, 2017, 50 (4), pp.1413--1422. ⟨10.3892/ijo.2017.3907⟩. ⟨hal-01517821⟩

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