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Macrophages and RhoA Pathway in Transplanted Organs

Abstract : RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also pivotal for proper functioning of immune cells including macrophages. By controlling actin cytoskeleton organization, RhoA pathway modulates macrophage's polarity and basic functions: phagocytosis, migration, and extracellular matrix degradation. Numerous studies indicate that macrophages are very important effectors contributing to acute and chronic rejection of transplanted organs. In this review we discuss the role of RhoA pathway in governance of macrophage's functions in terms of transplanted organs.
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Submitted on : Thursday, May 4, 2017 - 10:05:01 AM
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Yianzhu Liu, Jacek Z. Kubiak, Xian C. Li, Rafik M. Ghobrial, Malgorzata Kloc. Macrophages and RhoA Pathway in Transplanted Organs. Malgorzata Kloc (ed). Asymmetric Cell Division in Development, Differentiation and Cancer, 62, pp.365-376, 2017, ⟨10.1007/978-3-319-54090-0_15⟩. ⟨hal-01518006⟩



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