Improved and General Manganese-Catalyzed N-Methylation of Aromatic Amines Using Methanol

Jacob Neumann (1) , Saravanakumar Elangovan (2, 1) , Anke Spannenberg (1) , Kathrin Junge (1) , Matthias Beller (1)

1 LIKAT Rostock - Leibniz-Institut für Katalyse
2 ISCR - Institut des Sciences Chimiques de Rennes

A novel lutidine-based manganese PNP-pincer complex has been synthesized for the selective N-methylation of aromatic amines with methanol. Using borrowing hydrogen methodology, a selection of differently functionalized aniline derivatives is selectively methylated in good yields.

Keywords: borrowing hydrogen; methylation; pincer complex; amines; manganese

Domains: Chemical Sciences

Jacob Neumann, Saravanakumar Elangovan, Anke Spannenberg, Kathrin Junge, Matthias Beller. Improved and General Manganese-Catalyzed N-Methylation of Aromatic Amines Using Methanol. Chemistry - A European Journal, 2017, 23 (23), pp.5410-5413. ⟨10.1002/chem.201605218⟩. ⟨hal-01518033⟩