Skip to Main content Skip to Navigation
Journal articles

Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129

Abstract : Four bioactive compounds have been isolated from the fungus UBOCC-A-114129 cultivated from deep subsurface sediment. They were structurally characterized using a combination of LC-MS/MS and NMR analyses as fuscin and its derivatives (dihydrofuscin, dihydrosecofuscin, and secofuscin) and identified as polyketides. Albeit those compounds were already obtained from terrestrial fungi, this is the first report of their production by an species and by the deepest subseafloor isolate ever studied for biological activities. We report a weak antibacterial activity of dihydrosecofuscin and secofuscin mainly directed against Gram-positive bacteria (Minimum Inhibitory Concentration (MIC) equal to Minimum Bactericidal Concentration (MBC), in the range of 100 μg/mL). The activity on various protein kinases was also analyzed and revealed a significant inhibition of CDC2-like kinase-1 (CLK1) by dihysecofuscin.
Document type :
Journal articles
Complete list of metadatas

Cited literature [23 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01518044
Contributor : Laurent Jonchère <>
Submitted on : Thursday, May 3, 2018 - 2:31:33 PM
Last modification on : Friday, October 16, 2020 - 3:41:10 AM

File

marinedrugs-15-00111.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Marion Navarri, Camille Jégou, Arnaud Bondon, Sandrine Pottier, Stéphane Bach, et al.. Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129. Marine drugs, MDPI, 2017, 15 (4), ⟨10.3390/md15040111⟩. ⟨hal-01518044⟩

Share

Metrics

Record views

323

Files downloads

233