3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study

Abstract : Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2) than in women (82 and 35 mL/m2; P < 0.0001). Conversely, lower limits of LV ejection fraction were higher in women than in men (51% vs. 50%; P < 0.01). Similarly, all strain components were higher in women than in men. Lower range was -18.6% in men and -19.5% in women for 3D longitudinal strain, -27.0% and -27.6% for 3D circumferential strain, -33.2% and -34.4% for 3D tangential strain and 38.8% and 40.7% for 3D radial strain, respectively. LV volumes decreased with age in both genders (P < 0.0001), whereas LV ejection fraction increased with age only in men. Among 3DE LV strain components, the only one, which did not change with age was longitudinal strain. Conclusion: The NORRE study provides applicable 3D echocardiographic reference ranges for LV function assessment. Our data highlight the importance of age- and gender-specific reference values for both LV volumes and strain.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01518406
Contributor : Laurent Jonchère <>
Submitted on : Thursday, May 4, 2017 - 3:37:58 PM
Last modification on : Monday, September 24, 2018 - 2:37:29 PM

Links full text

Identifiers

Citation

Anne Bernard, Karima Addetia, Raluca Dulgheru, Luis Caballero, Tadafumi Sugimoto, et al.. 3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study. European Heart Journal - Cardiovascular Imaging, Oxford UP, 2017, 18, pp.475-483. ⟨10.1093/ehjci/jew284⟩. ⟨hal-01518406⟩

Share

Metrics

Record views

120