Dysmetabolic iron overload syndrome: a mild but unquestionable iron overload is identified by MRI

Fabrice Lainé (1, 2) , Edouard Bardou-Jacquet (2, 1) , Anita Paisant (2, 1) , Yves Gandon (1) , Yves Deugnier (2, 1)

1 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
2 CIC - Centre d'Investigation Clinique [Rennes]

Castiella et al. claim that liver iron concentration (LIC) is not increased in patients with hyperferritinemia and metabolic syndrome on the basis of a study[1] in which LIC was measured using magnetic resonance imaging (MRI) in 54 patients referred for hyperferritinemia. However, this study has a major limitation, because 5% of patients had viral hepatitis and 35% were excessive drinkers (>40 g/day), two conditions that can induce hyperferritinemia without iron overload.

Domaines: Hépatologie et Gastroentérologie

Fabrice Lainé, Edouard Bardou-Jacquet, Anita Paisant, Yves Gandon, Yves Deugnier. Dysmetabolic iron overload syndrome: a mild but unquestionable iron overload is identified by MRI. Hepatology, 2017, 65 (6), pp.2119-2120. ⟨10.1002/hep.29032⟩. ⟨hal-01531023⟩