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Journal articles
Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
Jean-François Arnal
1
Françoise Lenfant
1
Raphaël Métivier
2
Gilles Flouriot
3
Daniel Henrion
4
Marine Adlanmerini
1
Coralie Fontaine
1
Pierre Gourdy
1
Pierre Chambon
5
Benita Katzenellenbogen
6
John Katzenellenbogen
7
Jean-François Arnal 1
Author
Françoise Lenfant 1
Author
Raphaël Métivier 2
Author IdHAL : raphael-metivier ORCID : https://orcid.org/0000-0002-6524-0676
Gilles Flouriot 3
Author IdHAL : gilles-flouriot ORCID : https://orcid.org/0000-0001-6250-4173
Daniel Henrion 4
Author IdHAL : daniel-henrion ORCID : https://orcid.org/0000-0003-1094-0285
Marine Adlanmerini 1
Author
Coralie Fontaine 1
Author
Pierre Gourdy 1
Author
1
I2MC - Institut des Maladies Métaboliques et Cardiovasculaires (1 avenue du Prof Jean Poulhes - BP 84225 - 31432 Toulouse Cedex 4 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR1048 (101, rue de Tolbiac, 75013 Paris - France)
2
IGDR - Institut de Génétique et Développement de Rennes (Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6290 (France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
3
Irset - Institut de recherche en santé, environnement et travail (263 avenue Général Leclerc 35042 Rennes Cedex - France)
- UA - Université d'Angers (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- EHESP - École des Hautes Études en Santé Publique [EHESP] (15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1085 (101, rue de Tolbiac, 75013 Paris - France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
4
BNMI - Biologie Neurovasculaire et Mitochondriale Intégrée (France)
- CNRS - Centre National de la Recherche Scientifique (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- UA - Université d'Angers (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
5
IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire (Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1258 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7104 (France)
- UNISTRA - Université de Strasbourg : UMR7104 (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
6
Department of Molecular and Integrative Physiology (Urbana, IL - United States)
- University of Illinois System (108 Henry Administration Bldg. Urbana, IL 61801 - United States)
7
Department of Chemistry (505 S Mathews Ave Urbana, IL 61801 - United States)
- University of Illinois at Urbana-Champaign [Urbana] (205 N. Mathews Ave., Urbana-Champaign, IL 61801 - United States)
- University of Illinois System (108 Henry Administration Bldg. Urbana, IL 61801 - United States)
Abstract : Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a key role in reproduction and exerting functions in numerous nonreproductive tissues. In this review, we attempt to summarize the in vitro studies that are the basis of our current understanding of the mechanisms of action of ERα as a nuclear receptor and the key roles played by its two activation functions (AFs) in its transcriptional activities. We then depict the consequences of the selective inactivation of these AFs in mouse models, focusing on the prominent roles played by ERα in the reproductive tract and in the vascular system. Evidence has accumulated over the two last decades that ERα is also associated with the plasma membrane and activates non-nuclear signaling from this site. These rapid/nongenomic/membrane-initiated steroid signals (MISS) have been characterized in a variety of cell lines, and in particular in endothelial cells. The development of selective pharmacological tools that specifically activate MISS and the generation of mice expressing an ERα protein impeded for membrane localization have begun to unravel the physiological role of MISS in vivo. Finally, we discuss novel perspectives for the design of tissue-selective ER modulators based on the integration of the physiological and pathophysiological roles of MISS actions of estrogens.
Document type :
Journal articles
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Complete list of metadata
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01533249
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, June 6, 2017 - 11:20:20 AM
Last modification on : Wednesday, April 14, 2021 - 12:51:51 PM
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, June 6, 2017 - 11:20:20 AM
Last modification on : Wednesday, April 14, 2021 - 12:51:51 PM
Identifiers
- HAL Id : hal-01533249, version 1
- DOI : 10.1152/physrev.00024.2016
- PUBMED : 28539435
Collections
UNIV-RENNES1 | IGDR | CNRS | UNIV-ANGERS | IGBMC | IRSET | BIOSIT | IRSET-6 | UR1-UFR-SVE | SITE-ALSACE | UNIV-RENNES | UNIV-TLSE3
Citation
Jean-François Arnal, Françoise Lenfant, Raphaël Métivier, Gilles Flouriot, Daniel Henrion, et al.. Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications. Physiological Reviews, American Physiological Society, 2017, 97 (3), pp.1045-1087. ⟨10.1152/physrev.00024.2016⟩. ⟨hal-01533249⟩
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