Total Synthesis of γ-Indomycinone and Kidamycinone by Means of Two Regioselective Diels-Alder Reactions

Abstract : An efficient access for the synthesis of pluramycinones is described. Total syntheses of racemic γ-indomycinone and kidamycinone were achieved by means of two Diels-Alder reactions. A first Diels-Alder condensation followed by a Stille cross-coupling is used for the elaboration of the desired substituted dienes which will be involved in the second pericyclic reaction with juglone to construct the tetracyclic core of pluramycinones.
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Journal of Organic Chemistry, American Chemical Society, 2017, 82 (11), pp.5710-5719. 〈10.1021/acs.joc.7b00544〉
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Contributeur : Laurent Jonchère <>
Soumis le : mardi 6 juin 2017 - 12:12:02
Dernière modification le : jeudi 11 janvier 2018 - 06:25:21

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Thibaud Mabit, Aymeric Siard, Mathilde Pantin, Doumadé Zon, Laura Foulgoc, et al.. Total Synthesis of γ-Indomycinone and Kidamycinone by Means of Two Regioselective Diels-Alder Reactions. Journal of Organic Chemistry, American Chemical Society, 2017, 82 (11), pp.5710-5719. 〈10.1021/acs.joc.7b00544〉. 〈hal-01533331〉

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