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The route of infection determines Wolbachia antibacterial protection in Drosophila

Abstract : Bacterial symbionts are widespread among metazoans and provide a range of beneficial functions. -mediated protection against viral infection has been extensively demonstrated in In mosquitoes that are artificially transinfected with (wMel), protection from both viral and bacterial infections has been demonstrated. However, no evidence for -mediated antibacterial protection has been demonstrated in to date. Here, we show that the route of infection is key for -mediated antibacterial protection. carrying showed reduced mortality during enteric-but not systemic-infection with the opportunist pathogen -mediated protection was more pronounced in male flies and is associated with increased early expression of the antimicrobial peptide , and also increased expression of a reactive oxygen species detoxification gene (). These results highlight that the route of infection is important for symbiont-mediated protection from infection, that can protect hosts by eliciting a combination of resistance and disease tolerance mechanisms, and that these effects are sexually dimorphic. We discuss the importance of using ecologically relevant routes of infection to gain a better understanding of symbiont-mediated protection.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01544267
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Submitted on : Wednesday, June 21, 2017 - 3:15:52 PM
Last modification on : Monday, June 15, 2020 - 10:50:04 AM

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Vanika Gupta, Radhakrishnan B. Vasanthakrishnan, Jonathon Siva-Jothy, Katy M. Monteith, Sam P. Brown, et al.. The route of infection determines Wolbachia antibacterial protection in Drosophila. Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2017, 284 (1856), pp.1856. ⟨10.1098/rspb.2017.0809⟩. ⟨hal-01544267⟩

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