Synthesis of Propargylic Fluorides toward Carbo- and Heterocycles with Mono- and gem-Difluorinated Side Chains - Archive ouverte HAL Access content directly
Journal Articles Synthesis: Journal of Synthetic Organic Chemistry Year : 2017

Synthesis of Propargylic Fluorides toward Carbo- and Heterocycles with Mono- and gem-Difluorinated Side Chains

A. Hachem
  • Function : Author
D. Grée
  • Function : Correspondent author
S. Chandrasekhar
  • Function : Author
R. Grée
  • Function : Correspondent author

Abstract

This review reports the synthesis of propargylic derivatives with alkyl chains bearing either one fluorine or a gem-difluoro system. The preparation of the different categories of fluorinated derivatives is analyzed in a systematic manner, based on the nature of substituents close to the fluorine atom(s). In the second part of this review are summarized the synthetic applications of these fluorinated propargylic intermediates, focusing mainly on the preparation of carbo- and heterocyclic derivatives. 1 Introduction 2 Synthesis of Propargylic Fluorides 3 Use of Propargylic Fluorides in the Preparation of Carbo- and Heterocycles with Fluorine-Containing Side Chains 4 Conclusions and Perspectives © Georg Thieme VerlagStuttgart · New York.
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Dates and versions

hal-01544470 , version 1 (21-06-2017)

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A. Hachem, D. Grée, S. Chandrasekhar, R. Grée. Synthesis of Propargylic Fluorides toward Carbo- and Heterocycles with Mono- and gem-Difluorinated Side Chains. Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (10), pp.2101--2116. ⟨10.1055/s-0036-1589484⟩. ⟨hal-01544470⟩
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