Rare myopathy associated to MGUS, causing heart failure and responding to chemotherapy

Nicolas Belhomme (1) , Adel Maamar (1) , Thomas Le Gallou (1) , Marie-Christine Minot-Myhié (1) , Antoine Larralde (1) , Nicolas Champtiaux (2) , Olivier Benveniste (3, 2) , Sarah Leonard-Louis (3) , Olivier Decaux (1) , Alain Lescoat (1) , Yves Le Tulzo (4, 1)

1 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
2 CHU Pitié-Salpêtrière [AP-HP]
3 Centre de recherche en Myologie – U974 SU-INSERM
4 CIC - Centre d'Investigation Clinique [Rennes]

Monoclonal gammopathy of unknow significance (MGUS) has recently been described as a possible cause of sporadic late onset nemaline myopathy (SLONM), which can lead to severe muscle impairment and respiratory insufficiency. We report the case of a man presenting a MGUS related SLONM, whose singularity was a severe heart involvement...

Mots clés: Sporadic late onset nemaline myopathy; Monoclonal gammopathy of unknown significance; Heart failure; Nemaline myopathy related cardiomyopathy; Chemotherapy; Sarcoplasmic rods; Electron microscopy

Domaines: Hématologie

Nicolas Belhomme, Adel Maamar, Thomas Le Gallou, Marie-Christine Minot-Myhié, Antoine Larralde, et al.. Rare myopathy associated to MGUS, causing heart failure and responding to chemotherapy. Annals of Hematology, 2017, 96 (4), pp.695-696. ⟨10.1007/s00277-016-2916-3⟩. ⟨hal-01558317⟩