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Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia

Xavier Cahu 1 Martin Carré Christian Recher 2 Arnaud Pigneux 3 Mathilde Hunault-Berger 4, 5 Norbert Vey 6 Patrice Chevallier 7, 8 Jacques Delaunay 9 Emmanuel Gyan 10, 11, 12 Bruno Lioure 13 Caroline Bonmati 14 Chantal Himberlin 15 Yosr Hicheri Gaelle Guillerm 16 Bouscary Didier Fabrice Larosa 17 Mario Ojeda-Uribe 18 Marc Bernard 19, 20 Marie C. Bene 21 Norbert Ifrah 22 Jean-Yves Cahn 23
Abstract : OBJECTIVES: Anthracyclines and cytarabine are cornerstones for intensive chemotherapy in acute myeloid leukemia (AML). The goals of this study were to comprehensively assess deviations from theoretical doses and the impact of body-surface area (BSA) on patients' characteristics, physicians' strategy, dose adjustment, and clinical outcome. METHODS: The GOELAMS 2001 phase III trial included 823 AML patients below 60 years of age. In the course of treatment, anthropomorphic parameters and chemotherapy doses were prospectively registered. RESULTS: Very high BSA (≥2.15 m(2) ) was the factor most significantly associated with the physician's decision to reduce chemotherapy doses during induction and postremission therapy. Despite similar AML characteristics and therapeutic strategies, the very high BSA group exhibited a significantly worse survival (5-years OS of 27%) compared to the low (BSA≤1.5 m(2) ), intermediate (1.5 m(2)
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Submitted on : Monday, July 10, 2017 - 9:55:56 AM
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Xavier Cahu, Martin Carré, Christian Recher, Arnaud Pigneux, Mathilde Hunault-Berger, et al.. Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia. European Journal of Haematology, 2017, 98, pp.443-449. ⟨10.1111/ejh.12850⟩. ⟨hal-01558818⟩



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