Fluctuation Does Not Mean Variability: A Pharmacokinetic Point of View

F. Lemaître (1, 2, 3) , C. Tron (1, 2) , M. Rayar (2, 1)

1 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
2 CIC - Centre d'Investigation Clinique [Rennes]
3 Irset - Institut de recherche en santé, environnement et travail

To the Editor: We read with interest the article by Tremblay et al [1] recently published in the American Journal of Transplantation and wanted to congratulate the authors for their study... [1] : Tremblay S, Nigro V, Weinberg J, Woodle ES, Alloway RR. A steady-state head-to-head pharmacokinetic comparison of all FK-506 (tacrolimus) formulations (ASTCOFF): An open-label, prospective, randomized, two-arm, three-period crossover study. Am J Transplant 2017; 17: 432–442.

Mots clés: immunosuppressant; editorial/personal viewpoint; calcineurin inhibitor: tacrolimus; basic (laboratory) research/science; immunosuppression/immune modulation; Pharmacokinetics/pharmacodynamics; Pharmacology

Domaines: Sciences du Vivant [q-bio]; Sciences pharmaceutiques; Immunologie

F. Lemaître, C. Tron, M. Rayar. Fluctuation Does Not Mean Variability: A Pharmacokinetic Point of View. American Journal of Transplantation, 2017, 17 (6), pp.1691-1692. ⟨10.1111/ajt.14237⟩. ⟨hal-01558820⟩