M. Konstan, K. Hilliard, T. Norvell, and M. Berger, Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation., American Journal of Respiratory and Critical Care Medicine, vol.150, issue.2, pp.448-54, 1994.
DOI : 10.1164/ajrccm.150.2.8049828

S. Brennan, P. Sly, C. Gangell, N. Sturges, K. Winfield et al., Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis, European Respiratory Journal, vol.34, issue.3, pp.655-61, 2009.
DOI : 10.1183/09031936.00178508

URL : http://erj.ersjournals.com/content/erj/34/3/655.full.pdf

A. Wright, S. Rao, S. Range, C. Eder, T. Hofer et al., Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors, Journal of Leukocyte Biology, vol.86, issue.3, pp.479-89, 2009.
DOI : 10.1189/jlb.1108699

T. Cohen and A. Prince, Cystic fibrosis: a mucosal immunodeficiency syndrome, Nature Medicine, vol.17, issue.4, pp.509-528, 2012.
DOI : 10.1016/j.cell.2010.11.029

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577071

N. Fujiwara and K. Kobayashi, Macrophages in Inflammation, Current Drug Target -Inflammation & Allergy, vol.4, issue.3, pp.281-287, 2005.
DOI : 10.2174/1568010054022024

T. Noah, H. Black, P. Cheng, R. Wood, and M. Leigh, Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis, Journal of Infectious Diseases, vol.175, issue.3, pp.638-685, 1997.
DOI : 10.1093/infdis/175.3.638

URL : https://academic.oup.com/jid/article-pdf/175/3/638/6463028/175-3-638.pdf

S. Rao, A. Wright, W. Montiero, L. Ziegler-heitbrock, and J. Grigg, Monocyte chemoattractant chemokines in cystic fibrosis, Journal of Cystic Fibrosis, vol.8, issue.2, pp.97-103, 2009.
DOI : 10.1016/j.jcf.2008.09.009

URL : http://doi.org/10.1016/j.jcf.2008.09.009

E. Bruscia, P. Zhang, E. Ferreira, C. Caputo, J. Emerson et al., Mice, American Journal of Respiratory Cell and Molecular Biology, vol.40, issue.3, pp.295-3042008, 2009.
DOI : 10.1165/rcmb.2008-0170OC

R. Legssyer, F. Huaux, J. Lebacq, M. Delos, E. Marbaix et al., Azithromycin reduces spontaneous and induced inflammation in ??F508 cystic fibrosis mice, Respiratory Research, vol.174, issue.1, p.134, 2006.
DOI : 10.1093/infdis/174.5.994

URL : https://respiratory-research.biomedcentral.com/track/pdf/10.1186/1465-9921-7-134?site=respiratory-research.biomedcentral.com

T. Lawrence and G. Natoli, Transcriptional regulation of macrophage polarization: enabling diversity with identity, Nature Reviews Immunology, vol.204, issue.11, pp.750-61, 2011.
DOI : 10.1084/jem.20070075

A. Sica and A. Mantovani, Macrophage plasticity and polarization: in vivo veritas, Journal of Clinical Investigation, vol.122, issue.3, pp.787-95, 2012.
DOI : 10.1172/JCI59643DS1

URL : http://www.jci.org/articles/view/59643/files/pdf

B. Murphy, H. Bush, V. Sundareshan, C. Davis, J. Hagadone et al., Characterization of macrophage activation states in patients with cystic fibrosis, Journal of Cystic Fibrosis, vol.9, issue.5, pp.314-336, 2010.
DOI : 10.1016/j.jcf.2010.04.006

S. Claeys, H. Van-hoecke, G. Holtappels, P. Gevaert, D. Belder et al., Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.101, issue.4, pp.467-72, 2005.
DOI : 10.1006/bbrc.2000.4157

O. Krysko, T. Zele, S. Claeys, and C. Bachert, Comment on "Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients", The Journal of Immunology, vol.183, issue.8, pp.4831-4833, 2009.
DOI : 10.4049/jimmunol.0990081

T. Cory, S. Birket, B. Murphy, H. Jr, D. Anstead et al., Impact of azithromycin treatment on macrophage gene expression in subjects with cystic fibrosis, Journal of Cystic Fibrosis, vol.13, issue.2, pp.164-71, 2014.
DOI : 10.1016/j.jcf.2013.08.007

M. Meyer, F. Huaux, X. Gavilanes, S. Van-den-brûle, P. Lebecque et al., Azithromycin Reduces Exaggerated Cytokine Production by M1 Alveolar Macrophages in Cystic Fibrosis, American Journal of Respiratory Cell and Molecular Biology, vol.41, issue.5, pp.590-6022008, 2009.
DOI : 10.1165/rcmb.2008-0155OC

S. Schif-zuck, N. Gross, S. Assi, R. Rostoker, C. Serhan et al., Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids, European Journal of Immunology, vol.170, issue.2, pp.366-79, 2011.
DOI : 10.4049/jimmunol.170.12.6266

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082320

K. Yoshimura, H. Nakamura, B. Trapnell, C. Chu, W. Dalemans et al., Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin, Nucleic Acids Research, vol.19, issue.19, pp.5417-5440, 1991.
DOI : 10.1093/nar/19.19.5417

T. Bonfield, C. Hodges, C. Cotton, and M. Drumm, Absence of the cystic fibrosis transmembrane regulator (Cftr) from myeloid-derived cells slows resolution of inflammation and infection, Journal of Leukocyte Biology, vol.92, issue.5, pp.1111-1133, 2012.
DOI : 10.1189/jlb.0412188

A. Di, M. Brown, L. Deriy, C. Li, F. Szeto et al., CFTR regulates phagosome acidification in macrophages and alters bactericidal activity, Nature Cell Biology, vol.167, issue.9, pp.933-977, 2006.
DOI : 10.1074/jbc.M400688200

D. Porto, P. Cifani, N. Guarnieri, S. , D. Domenico et al., Dysfunctional CFTR Alters the Bactericidal Activity of Human Macrophages against Pseudomonas aeruginosa, PLoS ONE, vol.23, issue.5, 2011.
DOI : 10.1371/journal.pone.0019970.t001

K. Simonin-le-jeune, L. Jeune, A. Jouneau, S. Belleguic, C. Roux et al., Impaired Functions of Macrophage from Cystic Fibrosis Patients: CD11b, TLR-5 Decrease and sCD14, Inflammatory Cytokines Increase, PLoS ONE, vol.2, issue.9, 2013.
DOI : 10.1371/journal.pone.0075667.s007

URL : https://hal.archives-ouvertes.fr/inserm-00872278

E. Bruscia, P. Zhang, A. Satoh, C. Caputo, R. Medzhitov et al., Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic Fibrosis, The Journal of Immunology, vol.186, issue.12, pp.6990-6998, 2011.
DOI : 10.4049/jimmunol.1100396

L. Deriy, E. Gomez, G. Zhang, D. Beacham, J. Hopson et al., Disease-causing Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Determine the Functional Responses of Alveolar Macrophages, Journal of Biological Chemistry, vol.108, issue.51, pp.35926-35964, 2009.
DOI : 10.1099/mic.0.2008/023200-0

M. Ettorre, G. Verzè, S. Caldrer, J. Johansson, E. Calcaterra et al., Electrophysiological evaluation of Cystic Fibrosis Conductance Transmembrane Regulator (CFTR) expression in human monocytes, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1840, issue.10, pp.3088-95, 1840.
DOI : 10.1016/j.bbagen.2014.07.010

M. Cohen-cymberknoh, E. Kerem, T. Ferkol, and A. Elizur, Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications, Thorax, vol.30, issue.12, pp.1157-62, 2013.
DOI : 10.1038/nbt.2328

URL : http://thorax.bmj.com/content/thoraxjnl/68/12/1157.full.pdf

B. Kopp, B. Abdulrahman, A. Khweek, S. Kumar, A. Akhter et al., Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients, Biochemical and Biophysical Research Communications, vol.424, issue.2, pp.221-228, 2012.
DOI : 10.1016/j.bbrc.2012.06.066

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408781

J. Soltys, T. Bonfield, J. Chmiel, and M. Berger, Functional IL-10 Deficiency in the Lung of Cystic Fibrosis (cftr-/-) and IL-10 Knockout Mice Causes Increased Expression and Function of B7 Costimulatory Molecules on Alveolar Macrophages, The Journal of Immunology, vol.168, issue.4, pp.1903-1913, 1903.
DOI : 10.4049/jimmunol.168.4.1903

C. Andersson, M. Zaman, A. Jones, and S. Freedman, Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages, Journal of Cystic Fibrosis, vol.7, issue.1, pp.68-78, 2008.
DOI : 10.1016/j.jcf.2007.05.004

URL : http://doi.org/10.1016/j.jcf.2007.05.004

G. Thomas, E. Costelloe, D. Lunn, K. Stacey, S. Delaney et al., G551D Cystic Fibrosis Mice Exhibit Abnormal Regulation of Inflammation in Lungs and Macrophages, The Journal of Immunology, vol.164, issue.7, pp.3870-3877, 2000.
DOI : 10.4049/jimmunol.164.7.3870

J. Chmiel, M. Berger, and M. Konstan, The Role of Inflammation in the Pathophysiology of CF Lung Disease, Clinical Reviews in Allergy & Immunology, vol.23, issue.1, pp.5-27, 2002.
DOI : 10.1385/CRIAI:23:1:005

M. Ulrich, D. Worlitzsch, S. Viglio, N. Siegmann, P. Iadarola et al., Alveolar inflammation in cystic fibrosis, Journal of Cystic Fibrosis, vol.9, issue.3, pp.217-244, 2010.
DOI : 10.1016/j.jcf.2010.03.001

URL : http://doi.org/10.1016/j.jcf.2010.03.001

Y. Xu, A. Krause, H. Hamai, B. Harvey, T. Worgall et al., Proinflammatory Phenotype and Increased Caveolin-1 in Alveolar Macrophages with Silenced CFTR mRNA, PLoS ONE, vol.296, issue.6, 2010.
DOI : 10.1371/journal.pone.0011004.g005

Y. Zhang, X. Li, H. Grassmé, G. Döring, and E. Gulbins, Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection, The Journal of Immunology, vol.184, issue.9, pp.5104-5115, 1950.
DOI : 10.4049/jimmunol.0902851

M. Thomassen, C. Demko, R. Wood, B. Tandler, D. Dearborn et al., Ultrastructure and Function of Alveolar Macrophages from Cystic Fibrosis Patients, Pediatric Research, vol.14, issue.5, pp.715-736, 1980.
DOI : 10.1203/00006450-198005000-00003

E. Osika, J. Cavaillon, K. Chadelat, M. Boule, C. Fitting et al., Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease, European Respiratory Journal, vol.14, issue.2, pp.339-385, 1999.
DOI : 10.1183/09031936.99.14233999

T. Bonfield, J. Panuska, M. Konstan, K. Hilliard, J. Hilliard et al., Inflammatory cytokines in cystic fibrosis lungs., American Journal of Respiratory and Critical Care Medicine, vol.152, issue.6, pp.2111-2119, 1995.
DOI : 10.1164/ajrccm.152.6.8520783

S. Sagel, J. Chmiel, and M. Konstan, Sputum Biomarkers of Inflammation in Cystic Fibrosis Lung Disease, Proceedings of the American Thoracic Society, vol.4, issue.4, pp.406-17200703, 2007.
DOI : 10.1513/pats.200703-044BR

B. Lubamba, L. Jones, O. Neal, W. Boucher, R. Ribeiro et al., X-Box???Binding Protein 1 and Innate Immune Responses of Human Cystic Fibrosis Alveolar Macrophages, American Journal of Respiratory and Critical Care Medicine, vol.192, issue.12, pp.1449-61201504, 2015.
DOI : 10.1164/rccm.201504-0657OC

K. Pfeffer, T. Huecksteadt, and J. Hoidal, Expression and Regulation of Tumor Necrosis Factor in Macrophages from Cystic Fibrosis Patients, American Journal of Respiratory Cell and Molecular Biology, vol.9, issue.5, pp.511-520, 1993.
DOI : 10.1165/ajrcmb/9.5.511

S. Schmitt-grohé, C. Naujoks, J. Bargon, T. Wagner, R. Schubert et al., Interleukin-8 in whole blood and clinical status in cystic fibrosis, Cytokine, vol.29, pp.18-23, 2005.

O. Eickmeier, M. Huebner, E. Herrmann, U. Zissler, M. Rosewich et al., Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function, Cytokine, vol.50, issue.2, pp.152-159, 2010.
DOI : 10.1016/j.cyto.2010.02.004

D. Hartl, M. Griese, M. Kappler, G. Zissel, D. Reinhardt et al., Pulmonary TH2 response in Pseudomonas aeruginosa???infected patients with cystic fibrosis, Journal of Allergy and Clinical Immunology, vol.117, issue.1, pp.204-215, 2006.
DOI : 10.1016/j.jaci.2005.09.023

S. Jouneau, M. Bonizec, C. Belleguic, B. Desrues, G. Brinchault et al., Anti-Inflammatory Effect of Fluvastatin on IL-8 Production Induced by Pseudomonas aeruginosa and Aspergillus fumigatus Antigens in Cystic Fibrosis, PLoS ONE, vol.373, issue.8, 2011.
DOI : 10.1371/journal.pone.0022655.s002

URL : https://hal.archives-ouvertes.fr/hal-00680962

M. Muhlebach, P. Steward, M. Leigh, and T. Noah, Quantitation of Inflammatory Responses to Bacteria in Young Cystic Fibrosis and Control Patients, American Journal of Respiratory and Critical Care Medicine, vol.160, issue.1, pp.186-91, 1999.
DOI : 10.1164/ajrccm.160.1.9808096

M. Muhlebach, W. Reed, and T. Noah, Quantitative cytokine gene expression in CF airway, Pediatric Pulmonology, vol.58, issue.5, pp.393-402, 2004.
DOI : 10.1164/ajrccm.160.4.9901062

B. Oliver, S. Lim, P. Wark, V. Laza-stanca, N. King et al., Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages, Thorax, vol.63, issue.6, pp.519-544, 2008.
DOI : 10.1136/thx.2007.081752

URL : http://thorax.bmj.com/content/thoraxjnl/63/6/519.full.pdf

K. Tiringer, A. Treis, P. Fucik, M. Gona, S. Gruber et al., Infection, American Journal of Respiratory and Critical Care Medicine, vol.187, issue.6, pp.621-9201206, 2013.
DOI : 10.1164/rccm.201206-1150OC

T. Khan, J. Wagener, T. Bost, J. Martinez, F. Accurso et al., Early pulmonary inflammation in infants with cystic fibrosis, Am J Respir Crit Care Med, vol.151, pp.1075-82, 1995.
DOI : 10.1164/ajrccm/151.4.1075

M. Zaman, A. Gelrud, O. Junaidi, M. Regan, M. Warny et al., Interleukin 8 secretion from monocytes of subjects heterozygous for the ?F508 cystic fibrosis transmembrane conductance regulator gene mutation is altered, Clin Diagn Lab Immunol, vol.11, pp.819-843, 2004.

P. Zhang, J. Cheng, S. Zou, D. Souza, A. Koff et al., Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation, Nature Communications, vol.276, p.6221, 2015.
DOI : 10.1074/jbc.C100462200

O. Takeuchi and S. Akira, Pattern Recognition Receptors and Inflammation, Cell, vol.140, issue.6, pp.805-825, 2010.
DOI : 10.1016/j.cell.2010.01.022

URL : http://doi.org/10.1016/j.cell.2010.01.022

J. Sallenave, Phagocytic and signaling innate immune receptors: are they dysregulated in cystic fibrosis in the fight against Pseudomonas aeruginosa?, The International Journal of Biochemistry & Cell Biology, vol.52, pp.103-110, 2014.
DOI : 10.1016/j.biocel.2014.01.013

N. Sturges, M. Wikström, K. Winfield, S. Gard, S. Brennan et al., Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4, Pediatric Pulmonology, vol.56, issue.9, pp.883-892, 2010.
DOI : 10.1146/annurev.iy.12.040194.001041

D. Descamps, L. Gars, M. Balloy, V. Barbier, D. Maschalidi et al., Toll-like receptor 5 (TLR5), IL-1?? secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing, Proceedings of the National Academy of Sciences, vol.123, issue.4, pp.1619-1643, 2012.
DOI : 10.1038/sj.bjp.0701649

URL : https://hal.archives-ouvertes.fr/pasteur-00667246

T. Hofer, M. Frankenberger, I. Heimbeck, D. Burggraf, M. Wjst et al., Decreased expression of HLA-DQ and HLA-DR on cells of the monocytic lineage in cystic fibrosis, Journal of Molecular Medicine, vol.98, issue.Suppl 4, pp.1293-304, 2014.
DOI : 10.1093/qjmed/hci112

N. Alexis, M. Muhlebach, D. Peden, and T. Noah, Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients, Journal of Cystic Fibrosis, vol.5, issue.1, pp.17-25, 2006.
DOI : 10.1016/j.jcf.2005.11.001

G. Ross and V. V?tvicka, CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions, Clinical & Experimental Immunology, vol.54, issue.2, pp.181-185, 1993.
DOI : 10.1016/B978-0-12-256950-0.50018-7

J. Humphries, A. Byron, and M. Humphries, Integrin ligands at a glance, Journal of Cell Science, vol.119, issue.19, pp.3901-3904, 2006.
DOI : 10.1242/jcs.03098

URL : http://jcs.biologists.org/content/joces/119/19/3901.full.pdf

?. Van-de-weert, P. Van-leeuwen, M. Van-meegen, J. Speirs, D. Pals et al., by Monocytes Is Cystic Fibrosis Transmembrane Conductance Regulator???Dependent, American Journal of Respiratory Cell and Molecular Biology, vol.49, issue.3, pp.463-702012, 2013.
DOI : 10.1165/rcmb.2012-0502OC

R. Stokes, I. Haidl, W. Jefferies, and D. Speert, Mycobacteria-macrophage interactions. Macrophage phenotype determines the nonopsonic binding of Mycobacterium tuberculosis to murine macrophages, J Immunol, vol.151, pp.7067-76, 1993.

C. Cywes, N. Godenir, H. Hoppe, R. Scholle, L. Steyn et al., Nonopsonic binding of Mycobacterium tuberculosis to human complement receptor type 3 expressed in Chinese hamster ovary cells, Infect Immun, vol.64, pp.5373-83, 1996.

D. Russell and S. Wright, Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes, Journal of Experimental Medicine, vol.168, issue.1, pp.279-92, 1988.
DOI : 10.1084/jem.168.1.279

C. Sorio, A. Montresor, M. Bolomini-vittori, S. Caldrer, B. Rossi et al., Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency, American Journal of Respiratory and Critical Care Medicine, vol.193, issue.10, pp.1123-33201510, 2015.
DOI : 10.1164/rccm.201510-1922OC

R. Vandivier, V. Fadok, P. Hoffmann, D. Bratton, C. Penvari et al., Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis, Journal of Clinical Investigation, vol.109, issue.5, pp.661-70, 2002.
DOI : 10.1172/JCI0213572

O. Vieira, R. Botelho, and S. Grinstein, Phagosome maturation: aging gracefully, Biochemical Journal, vol.366, issue.3, 2002.
DOI : 10.1042/bj20020691

B. Abdulrahman, A. Khweek, A. Akhter, K. Caution, S. Kotrange et al., in a model of cystic fibrosis, Autophagy, vol.7, issue.11, pp.1359-70, 2011.
DOI : 10.1164/rccm.200802-220OC

J. Bessich, A. Nymon, L. Moulton, D. Dorman, and A. Ashare, Low Levels of Insulin-like Growth Factor-1 Contribute to Alveolar Macrophage Dysfunction in Cystic Fibrosis, The Journal of Immunology, vol.191, issue.1, pp.378-85, 2013.
DOI : 10.4049/jimmunol.1300221

N. Cifani, B. Pompili, M. Anile, M. Patella, D. Diso et al., Reactive-Oxygen-Species-Mediated P. aeruginosa Killing Is Functional in Human Cystic Fibrosis Macrophages, PLoS ONE, vol.170, issue.8, 2013.
DOI : 10.1371/journal.pone.0071717.s004

P. Haggie and A. Verkman, Cystic Fibrosis Transmembrane Conductance Regulator-independent Phagosomal Acidification in Macrophages, Journal of Biological Chemistry, vol.7, issue.43, pp.31422-31430, 2007.
DOI : 10.1074/jbc.M511030200

URL : http://www.jbc.org/content/282/43/31422.full.pdf

H. Barriere, M. Bagdany, F. Bossard, T. Okiyoneda, G. Wojewodka et al., Revisiting the Role of Cystic Fibrosis Transmembrane Conductance Regulator and Counterion Permeability in the pH Regulation of Endocytic Organelles, Molecular Biology of the Cell, vol.20, issue.13, pp.3125-3166, 2009.
DOI : 10.1091/mbc.E09-01-0061

P. Haggie and A. Verkman, Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis, AJP: Lung Cellular and Molecular Physiology, vol.296, issue.6, pp.859-67, 2009.
DOI : 10.1152/ajplung.00018.2009

A. Radtke, K. Anderson, M. Davis, M. Dimagno, J. Swanson et al., Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome, Proceedings of the National Academy of Sciences, vol.156, issue.6, pp.1633-1641, 2011.
DOI : 10.1083/jcb.200201081

URL : http://www.pnas.org/content/108/4/1633.full.pdf

B. Abdulrahman, A. Khweek, A. Akhter, K. Caution, M. Tazi et al., to the Autophagic Machinery, Journal of Biological Chemistry, vol.3, issue.3, pp.2049-58, 2013.
DOI : 10.1016/S0076-6879(08)03237-0

K. Assani, M. Tazi, A. Amer, and B. Kopp, IFN-?? Stimulates Autophagy-Mediated Clearance of Burkholderia cenocepacia in Human Cystic Fibrosis Macrophages, PLoS ONE, vol.7, issue.5, p.96681, 2014.
DOI : 10.1371/journal.pone.0096681.s003

H. Grassmé, V. Jendrossek, A. Riehle, G. Von-kürthy, J. Berger et al., Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts, Nature Medicine, vol.9, issue.3, pp.322-352, 2003.
DOI : 10.1038/nm823

E. Gulbins, S. Dreschers, B. Wilker, and H. Grassmé, Ceramide, membrane rafts and infections, Journal of Molecular Medicine, vol.82, issue.6, pp.357-63, 2004.
DOI : 10.1007/s00109-004-0539-y

M. Kowalski and G. Pier, Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells Is Required for Pseudomonas aeruginosa-Induced Cellular Activation, The Journal of Immunology, vol.172, issue.1, pp.418-443, 1950.
DOI : 10.4049/jimmunol.172.1.418

X. Wang, H. Kim, K. Nakahira, S. Ryter, and A. Choi, The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1, The Journal of Immunology, vol.182, issue.6, pp.3809-3827, 2009.
DOI : 10.4049/jimmunol.0712437

P. Zhang, T. Murray, V. Villella, E. Ferrari, S. Esposito et al., Reduced Caveolin-1 Promotes Hyperinflammation due to Abnormal Heme Oxygenase-1 Localization in Lipopolysaccharide-Challenged Macrophages with Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator, The Journal of Immunology, vol.190, issue.10, pp.5196-206, 1950.
DOI : 10.4049/jimmunol.1201607

F. Schroeder, A. Gallegos, B. Atshaves, S. Storey, A. Mcintosh et al., Recent Advances in Membrane Microdomains: Rafts, Caveolae, and Intracellular Cholesterol Trafficking, Experimental Biology and Medicine, vol.34, issue.40, pp.873-90, 2001.
DOI : 10.1021/bi00031a008

Y. Xu, C. Tertilt, A. Krause, L. Quadri, R. Crystal et al., Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells, Respiratory Research, vol.278, issue.11, p.26, 2009.
DOI : 10.1074/jbc.M300304200

K. Becker, J. Riethmüller, Y. Zhang, and E. Gulbins, The Role of Sphingolipids and Ceramide in Pulmonary Inflammation in Cystic Fibrosis, The Open Respiratory Medicine Journal, vol.4, issue.1, pp.39-47, 2010.
DOI : 10.2174/1874306401004010039

K. Becker, J. Riethmüller, A. Lüth, G. Döring, B. Kleuser et al., Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis, American Journal of Respiratory Cell and Molecular Biology, vol.42, issue.6, pp.716-740, 2010.
DOI : 10.1165/rcmb.2009-0174OC

H. Grassmé, A. Carpinteiro, M. Edwards, E. Gulbins, and K. Becker, Regulation of the Inflammasome by Ceramide in Cystic Fibrosis Lungs, Cellular Physiology and Biochemistry, vol.34, issue.1, pp.45-55, 2014.
DOI : 10.1159/000362983

C. Guilbault, D. Sanctis, J. Wojewodka, G. Saeed, Z. Lachance et al., Fenretinide Corrects Newly Found Ceramide Deficiency in Cystic Fibrosis, American Journal of Respiratory Cell and Molecular Biology, vol.38, issue.1, pp.47-562007, 2008.
DOI : 10.1165/rcmb.2007-0036OC

V. Teichgräber, M. Ulrich, N. Endlich, J. Riethmüller, B. Wilker et al., Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis, Nature Medicine, vol.172, issue.4, pp.382-91, 2008.
DOI : 10.1097/00000542-197705000-00002

H. Yu, Y. Zeidan, B. Wu, R. Jenkins, T. Flotte et al., Infection in Cystic Fibrosis, American Journal of Respiratory Cell and Molecular Biology, vol.41, issue.3, pp.367-752008, 2009.
DOI : 10.1165/rcmb.2008-0295OC

Y. Zhang, X. Li, A. Carpinteiro, and E. Gulbins, Acid Sphingomyelinase Amplifies Redox Signaling in Pseudomonas aeruginosa-Induced Macrophage Apoptosis, The Journal of Immunology, vol.181, issue.6, pp.4247-54, 1950.
DOI : 10.4049/jimmunol.181.6.4247

URL : http://www.jimmunol.org/content/jimmunol/181/6/4247.full.pdf

C. Glass and S. Ogawa, Combinatorial roles of nuclear receptors in inflammation and immunity, Nature Reviews Immunology, vol.19, issue.1, pp.44-55, 2006.
DOI : 10.4049/jimmunol.168.5.2508

S. Cuzzocrea, E. Mazzon, R. Paola, A. Peli, A. Bonato et al., The role of the peroxisome proliferator-activated receptor-?? (PPAR-??) in the regulation of acute inflammation, Journal of Leukocyte Biology, vol.79, issue.5, pp.999-1010, 2006.
DOI : 10.1189/jlb.0605341

C. Jiang, A. Ting, and B. Seed, PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines, Nature, vol.391, pp.82-88, 1998.

B. Maskrey, A. Bermúdez-fajardo, A. Morgan, S. , E. Dioszeghy et al., Activated Platelets and Monocytes Generate Four Hydroxyphosphatidylethanolamines via Lipoxygenase, Journal of Biological Chemistry, vol.266, issue.28, pp.20151-63, 2007.
DOI : 10.1165/ajrcmb.20.1.3151

URL : http://www.jbc.org/content/282/28/20151.full.pdf

A. Morgan, V. Dioszeghy, B. Maskrey, C. Thomas, S. Clark et al., Phosphatidylethanolamine-esterified Eicosanoids in the Mouse, Journal of Biological Chemistry, vol.13, issue.32, pp.21185-91, 2009.
DOI : 10.1074/jbc.273.48.32023

V. Hammond, A. Morgan, S. Lauder, C. Thomas, S. Brown et al., Novel Keto-phospholipids Are Generated by Monocytes and Macrophages, Detected in Cystic Fibrosis, and Activate Peroxisome Proliferator-activated Receptor-??, Journal of Biological Chemistry, vol.72, issue.69, pp.41651-66, 2012.
DOI : 10.4049/jimmunol.0903594

URL : http://www.jbc.org/content/287/50/41651.full.pdf

O. Oskolkova, T. Afonyushkin, B. Preinerstorfer, W. Bicker, E. Von-schlieffen et al., Oxidized Phospholipids Are More Potent Antagonists of Lipopolysaccharide than Inducers of Inflammation, The Journal of Immunology, vol.185, issue.12, pp.7706-7718, 1950.
DOI : 10.4049/jimmunol.0903594

S. Brennan, G. Hall, F. Horak, A. Moeller, P. Pitrez et al., Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation, Thorax, vol.60, issue.2, pp.159-63, 2005.
DOI : 10.1136/thx.2004.026419