Skip to Main content Skip to Navigation
Journal articles

Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects?

Abstract : In mammals, the effects of estrogen are mainly mediated by two different estrogen receptors, ERα and ERβ. These proteins are members of the nuclear receptor family, characterized by distinct structural and functional domains, and participate in the regulation of different biological processes, including cell growth, survival and differentiation. The two estrogen receptor (ER) subtypes are generated from two distinct genes and have partially distinct expression patterns. Their activities are modulated differently by a range of natural and synthetic ligands. Some of these ligands show agonistic or antagonistic effects depending on ER subtype and are described as selective ER modulators (SERMs). Accordingly, a few phytochemicals, called phytoestrogens, which are synthesized from plants and vegetables, show low estrogenic activity or anti-estrogenic activity with potentially anti-proliferative effects that offer nutraceutical or pharmacological advantages. These compounds may be used as hormonal substitutes or as complements in breast cancer treatments. In this review, we discuss and summarize the in vitro and in vivo effects of certain phytoestrogens and their potential roles in the interaction with estrogen receptors.
Document type :
Journal articles
Complete list of metadata

Cited literature [146 references]  Display  Hide  Download
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, June 20, 2018 - 3:06:17 PM
Last modification on : Thursday, September 1, 2022 - 11:11:14 AM


Lecomte - Phytochemicals Targe...
Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



Sylvain Lecomte, Florence Demay, François Ferrière, Farzad Pakdel. Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects?. International Journal of Molecular Sciences, MDPI, 2017, 18 (7), pp.1381. ⟨10.3390/ijms18071381⟩. ⟨hal-01560283⟩



Record views


Files downloads