L. Ware, J. Bastarache, and L. Wang, Coagulation and fibrinolysis in human acute lung injury-New therapeutic targets?, The Keio Journal of Medicine, vol.54, issue.3, pp.142-151, 2005.
DOI : 10.2302/kjm.54.142

J. Hofstra, N. Juffermans, M. Schultz, and M. Zweers, Pulmonary Coagulopathy as a New Target in Lung Injury - A Review of Available Pre-Clinical Models, Current Medicinal Chemistry, vol.15, issue.6, pp.588-95, 2008.
DOI : 10.2174/092986708783769696

G. Choi, E. Wolthuis, P. Bresser, M. Levi, T. Van-der-poll et al., Mechanical Ventilation with Lower Tidal Volumes and Positive End-expiratory Pressure Prevents Alveolar Coagulation in Patients without Lung Injury, Anesthesiology, vol.105, issue.4, pp.689-95, 2006.
DOI : 10.1097/00000542-200610000-00013

J. Finigan, The coagulation system and pulmonary endothelial function in acute lung injury, Microvascular Research, vol.77, issue.1, pp.35-43, 2009.
DOI : 10.1016/j.mvr.2008.09.002

C. Santos and A. Slutsky, Mechanotransduction, ventilator-induced lung injury and multiple organ dysfunction syndrome, Intensive Care Medicine, vol.26, issue.5, pp.638-680, 2000.
DOI : 10.1007/s001340051217

R. Oeckler and R. Hubmayr, Ventilator-associated lung injury: a search for better therapeutic targets, European Respiratory Journal, vol.30, issue.6, pp.1216-1242, 2007.
DOI : 10.1183/09031936.00104907
URL : http://erj.ersjournals.com/content/erj/30/6/1216.full.pdf

J. Villar, J. Blanco, J. Añón, A. Santos-bouza, L. Blanch et al., The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation, Intensive Care Medicine, vol.179, issue.12, pp.1932-1973, 2011.
DOI : 10.1164/rccm.200805-722OC

S. Idell, Anticoagulants for Acute Respiratory Distress Syndrome, American Journal of Respiratory and Critical Care Medicine, vol.95, issue.4, pp.517-537, 2001.
DOI : 10.1164/ajrccm.161.2.9902403

P. Tuinman, B. Dixon, M. Levi, N. Juffermans, and M. Schultz, Nebulized anticoagulants for acute lung injury - a systematic review of preclinical and clinical investigations, Critical Care, vol.16, issue.2, p.70, 2012.
DOI : 10.1097/01.shk.0000129201.38588.85
URL : https://ccforum.biomedcentral.com/track/pdf/10.1186/cc11325?site=ccforum.biomedcentral.com

B. Dixon, M. Schultz, J. Hofstra, D. Campbell, and J. Santamaria, Nebulized heparin reduces levels of pulmonary coagulation activation in acute lung injury, Critical Care, vol.14, issue.5, p.445, 2010.
DOI : 10.1186/cc9269
URL : https://ccforum.biomedcentral.com/track/pdf/10.1186/cc9269?site=ccforum.biomedcentral.com

G. Glas, S. Neto, A. Horn, J. Cochran, A. Dixon et al., Nebulized heparin for patients under mechanical ventilation: an individual patient data meta-analysis. Ann Intensive Care, p.33, 2016.
DOI : 10.1186/s13613-016-0138-4
URL : https://annalsofintensivecare.springeropen.com/track/pdf/10.1186/s13613-016-0138-4?site=annalsofintensivecare.springeropen.com

F. Jaimes, D. L. Rosa, G. Morales, C. Fortich, F. Arango et al., Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)*, Critical Care Medicine, vol.37, issue.4, pp.1185-96, 2009.
DOI : 10.1097/CCM.0b013e31819c06bc

G. Glas, J. Muller, J. Binnekade, B. Cleffken, K. Colpaert et al., HEPBURN - investigating the efficacy and safety of nebulized heparin versus placebo in burn patients with inhalation trauma: study protocol for a multi-center randomized controlled trial, Trials, vol.15, issue.1, p.91, 2014.
DOI : 10.1186/cc6894

A. Miller, E. Elamin, and A. Suffredini, Inhaled Anticoagulation Regimens for the Treatment of Smoke Inhalation???Associated Acute Lung Injury, Critical Care Medicine, vol.42, issue.2, pp.413-422, 2014.
DOI : 10.1097/CCM.0b013e3182a645e5

N. Elsharnouby, H. Eid, A. Elezz, N. Aboelatta, and Y. , Heparin/Nacetylcysteine: an adjuvant in the management of burn inhalation injury: a study of different doses, J Crit Care, vol.29, pp.182-183, 2014.

M. Ledson, M. Gallagher, C. Hart, and M. Walshaw, Nebulized heparin in Burkholderia cepacia colonized adult cystic fibrosis patients, European Respiratory Journal, vol.17, issue.1, pp.36-44, 2001.
DOI : 10.1183/09031936.01.17100360
URL : http://erj.ersjournals.com/content/erj/17/1/36.full.pdf

K. Bendstrup, J. Gram, and J. Jensen, Effect of inhaled heparin on lung function and coagulation in healthy volunteers, European Respiratory Journal, vol.19, issue.4, pp.606-616, 2002.
DOI : 10.1183/09031936.02.00105202
URL : http://erj.ersjournals.com/content/erj/19/4/606.full.pdf

X. Li, Z. Zheng, X. Li, and X. Ma, Unfractionated heparin inhibits lipopolysaccharide-induced inflammatory response through blocking p38 MAPK and NF-??B activation on endothelial cell, Cytokine, vol.60, issue.1, pp.114-135, 2012.
DOI : 10.1016/j.cyto.2012.06.008

S. Fuchs, A. Hollins, M. Laue, U. Schaefer, K. Roemer et al., Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C, Cell and Tissue Research, vol.311, issue.1, pp.31-45, 2003.
DOI : 10.1007/s00441-002-0653-5

I. Witherden, V. Bon, E. Goldstraw, P. Ratcliffe, C. Pastorino et al., Primary Human Alveolar Type II Epithelial Cell Chemokine Release, American Journal of Respiratory Cell and Molecular Biology, vol.30, issue.4, pp.500-509, 2004.
DOI : 10.1074/jbc.M107736200

M. Johnell, G. Elgue, R. Larsson, A. Larsson, S. Thelin et al., Coagulation, fibrinolysis, and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated surface, The Journal of Thoracic and Cardiovascular Surgery, vol.124, issue.2, pp.321-353, 2002.
DOI : 10.1067/mtc.2002.122551
URL : https://doi.org/10.1067/mtc.2002.122551

M. Bouma, J. Maessen, P. Weerwind, M. Dentener, E. Fransen et al., Release of Lipopolysaccharide Toxicity-Modulating Proteins in Patients Undergoing Cardiopulmonary Bypass Using Noncoated and Heparin-Coated Extracorporeal Circuits, Chest, vol.111, issue.3, pp.577-83, 1997.
DOI : 10.1378/chest.111.3.577

F. Ning, X. Wang, L. Shang, T. Wang, C. Lv et al., Low molecular weight heparin may prevent acute lung injury induced by sepsis in rats, Gene, vol.557, issue.1, pp.88-91, 2015.
DOI : 10.1016/j.gene.2014.12.018

F. Puig, G. Fuster, M. Adda, L. Blanch, R. Farre et al., Barrier-Protective Effects of Activated Protein C in Human Alveolar Epithelial Cells, PLoS ONE, vol.32, issue.2, p.56965, 2013.
DOI : 10.1371/journal.pone.0056965.s004

R. Zarychanski, S. Doucette, D. Fergusson, D. Roberts, D. Houston et al., Early intravenous unfractionated heparin and mortality in septic shock*, Critical Care Medicine, vol.36, issue.11, pp.2973-2982, 2008.
DOI : 10.1097/CCM.0b013e31818b8c6b
URL : http://www.ubccriticalcaremedicine.ca/academic/jc_article/IV+Heparin+and+Mortality+in+Septic+Shock+Kumar+CCM+08+%28Mar-26-09%29.pdf

P. Suter, Nebulised heparin: a new approach to the treatment of acute lung injury? Crit Care Lond Engl, p.170, 2008.

W. Aird, The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome, Blood, vol.101, issue.10, pp.3765-77, 2003.
DOI : 10.1182/blood-2002-06-1887

N. Haeffner-cavaillon, J. Cavaillon, M. Moreau, and L. Szabó, Interleukin 1 secretion by human monocytes stimulated by the isolated polysaccharide region of the Bordetella pertussis endotoxin, Molecular Immunology, vol.21, issue.5, pp.389-95, 1984.
DOI : 10.1016/0161-5890(84)90036-1

K. Raymondos, M. Martin, T. Schmudlach, S. Baus, C. Weilbach et al., Early alveolar and systemic mediator release in patients at different risks for ARDS after multiple trauma, Injury, vol.43, issue.2, pp.189-95, 2012.
DOI : 10.1016/j.injury.2011.05.034

N. Aggarwal, L. King, D. Alessio, and F. , Diverse macrophage populations mediate acute lung inflammation and resolution, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.55, issue.8, pp.709-725, 2014.
DOI : 10.1038/358167a0
URL : http://ajplung.physiology.org/content/ajplung/306/8/L709.full.pdf

F. Bozza, J. Salluh, A. Japiassu, M. Soares, E. Assis et al., Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis, Critical Care, vol.11, issue.2, p.49, 2007.
DOI : 10.1186/cc5783

E. Mu, R. Ding, X. An, X. Li, S. Chen et al., Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-??/Smad signaling pathway, Thrombosis Research, vol.129, issue.4, pp.479-85, 2012.
DOI : 10.1016/j.thromres.2011.10.003

Y. Feng, Q. Yang, J. Xu, G. Qian, and Y. Liu, Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury, Experimental and Molecular Pathology, vol.85, issue.3, pp.214-236, 2008.
DOI : 10.1016/j.yexmp.2008.09.002

F. Puig, R. Herrero, R. Guillamat-prats, M. Gómez, J. Tijero et al., A New Experimental Model of Acid and Endotoxin-Induced Acute Lung Injury in Rats, American Journal of Physiology - Lung Cellular and Molecular Physiology
DOI : 10.1152/ajplung.00390.2015