M. Brignole, A. Auricchio, G. Baron-esquivias, P. Bordachar, G. Boriani et al., ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA), pp.2281-2329, 2013.

A. Epstein, J. Dimarco, K. Ellenbogen, N. Estes, R. Freedman et al., 2012 ACCF/AHA/HRS Focused Update Incorporated Into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society, American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society, pp.283-352, 2013.
DOI : 10.1161/CIR.0b013e318276ce9b

W. Abraham, W. Fisher, A. Smith, D. Delurgio, A. Leon et al., Cardiac Resynchronization in Chronic Heart Failure, New England Journal of Medicine, vol.346, issue.24, pp.1845-1853, 2002.
DOI : 10.1056/NEJMoa013168

J. Cleland, J. Daubert, E. Erdmann, N. Freemantle, D. Gras et al., The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure, New England Journal of Medicine, vol.352, issue.15, pp.1539-1549, 2005.
DOI : 10.1056/NEJMoa050496

E. Chung, A. Leon, L. Tavazzi, J. Sun, P. Nihoyannopoulos et al., Results of the Predictors of Response to CRT (PROSPECT) Trial, Circulation, vol.117, issue.20, pp.2608-2616, 2008.
DOI : 10.1161/CIRCULATIONAHA.107.743120

G. Boriani, B. Gardini, I. Diemberger, B. Reggiani, M. Biffi et al., Meta-analysis of randomized controlled trials evaluating left ventricular vs. biventricular pacing in heart failure: effect on all-cause mortality and hospitalizations, European Journal of Heart Failure, vol.12, issue.Suppl 2, pp.652-660, 2012.
DOI : 10.1093/eurjhf/hfq192

B. Thibault, A. Ducharme, F. Harel, M. White, O. Meara et al., Left Ventricular Versus Simultaneous Biventricular Pacing in Patients With Heart Failure and a QRS Complex >=120 Milliseconds, Circulation, vol.124, issue.25, pp.2874-2881, 2011.
DOI : 10.1161/CIRCULATIONAHA.111.032904
URL : http://circ.ahajournals.org/content/circulationaha/124/25/2874.full.pdf

G. Boriani, W. Kranig, E. Donal, L. Calo, M. Casella et al., A randomized double-blind comparison of biventricular versus left ventricular stimulation for cardiac resynchronization therapy: The Biventricular versus Left Univentricular Pacing with ICD Back-up in Heart Failure Patients (B-LEFT HF) trial, American Heart Journal, vol.159, issue.6, pp.1052-1058, 2010.
DOI : 10.1016/j.ahj.2010.03.008
URL : https://hal.archives-ouvertes.fr/hal-00909429

B. Van-gelder, F. Bracke, A. Meijer, and N. Pijls, The Hemodynamic Effect of Intrinsic Conduction During Left Ventricular Pacing as Compared to Biventricular Pacing, Journal of the American College of Cardiology, vol.46, issue.12, pp.2305-2310, 2005.
DOI : 10.1016/j.jacc.2005.02.098

K. Lee, J. Burnes, T. Mullen, D. Hettrick, H. Tse et al., Avoidance of Right Ventricular Pacing in Cardiac Resynchronization Therapy Improves Right Ventricular Hemodynamics in Heart Failure Patients, Journal of Cardiovascular Electrophysiology, vol.6, issue.5, pp.497-504, 2007.
DOI : 10.1046/j.1540-8167.2005.40777.x

M. Bertini, V. Delgado, and J. Bax, Why, how and when do we need to optimize the setting of cardiac resynchronization therapy?, Europace, vol.93, issue.12, pp.46-57, 2009.
DOI : 10.1016/j.amjcard.2004.02.061
URL : https://academic.oup.com/europace/article-pdf/11/suppl_5/v46/7533230/eup275.pdf

B. Vidal, M. Sitges, A. Marigliano, V. Delgado, E. Diaz-infante et al., Optimizing the Programation of Cardiac Resynchronization Therapy Devices in Patients With Heart Failure and Left Bundle Branch Block, The American Journal of Cardiology, vol.100, issue.6, pp.1002-1006, 2007.
DOI : 10.1016/j.amjcard.2007.04.046

K. Ellenbogen, M. Gold, T. Meyer, F. Lozano, I. Mittal et al., Primary Results From the SmartDelay Determined AV Optimization: A Comparison to Other AV Delay Methods Used in Cardiac Resynchronization Therapy (SMART-AV) Trial: A Randomized Trial Comparing Empirical, Echocardiography-Guided, and Algorithmic Atrioventricular Delay Programming in Cardiac Resynchronization Therapy, Circulation, vol.122, issue.25, pp.2660-2668, 2010.
DOI : 10.1161/CIRCULATIONAHA.110.992552

B. Terradellas, J. Delnoy, P. Brachmann, J. Reynolds, D. Padeletti et al., Clinical response to cardiac resynchronization therapy with the SonR hemodynamic sensor: the RESPOND-CRT Randomized Trial, Heart Rhythm, vol.16, pp.1-0401369, 2016.

P. Ritter, P. Delnoy, L. Padeletti, M. Lunati, H. Naegele et al., A randomized pilot study of optimization of cardiac resynchronization therapy in sinus rhythm patients using a peak endocardial acceleration sensor vs. standard methods, Europace, vol.32, issue.11, pp.1324-1333, 2012.
DOI : 10.1111/j.1540-8159.2008.02294.x

H. Krum, B. Lemke, D. Birnie, K. Lee, K. Aonuma et al., A novel algorithm for individualized cardiac resynchronization therapy: Rationale and design of the adaptive cardiac resynchronization therapy trial, American Heart Journal, vol.163, issue.5, pp.747-752, 2012.
DOI : 10.1016/j.ahj.2012.02.007

G. Daoud and M. Houmsse, Cardiac resynchronization therapy pacemaker: critical appraisal of the adaptive CRT-P device, Med Devices (Auckl), vol.9, pp.19-25, 2016.

D. Martin, B. Lemke, D. Birnie, H. Krum, K. Lee et al., Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: Results of the adaptive CRT trial, Houmsse M; Adaptive CRT Study Investigators, pp.1807-1814, 2012.
DOI : 10.1016/j.hrthm.2012.07.009

D. Birnie, B. Lemke, K. Aonuma, H. Krum, K. Lee et al., Clinical outcomes with synchronized left ventricular pacing: Analysis of the adaptive CRT trial, Heart Rhythm, vol.10, issue.9, pp.1368-1374, 2013.
DOI : 10.1016/j.hrthm.2013.07.007

J. Singh, W. Abraham, E. Chung, T. Rogers, A. Sambelashvili et al., Clinical response with adaptive CRT algorithm compared with CRT with echocardiography-optimized atrioventricular delay: a retrospective analysis of multicentre trials, Europace, vol.123, issue.11, pp.1622-1628, 2013.
DOI : 10.1161/CIRCULATIONAHA.110.000646
URL : https://academic.oup.com/europace/article-pdf/15/11/1622/7278637/eut107.pdf

D. Strauss, R. Selvester, and G. Wagner, Defining Left Bundle Branch Block in the Era of Cardiac Resynchronization Therapy, The American Journal of Cardiology, vol.107, issue.6, pp.927-934, 2011.
DOI : 10.1016/j.amjcard.2010.11.010

M. Gheorghiade, F. Zannad, G. Sopko, L. Klein, I. Pina et al., Acute Heart Failure Syndromes: Current State and Framework for Future Research, Circulation, vol.112, issue.25, pp.3958-3968, 2005.
DOI : 10.1161/CIRCULATIONAHA.105.590091
URL : http://circ.ahajournals.org/content/circulationaha/112/25/3958.full.pdf

N. Okumura, P. Jhund, J. Gong, M. Lefkowitz, A. Rizkala et al., Importance of Clinical Worsening of Heart Failure Treated in the Outpatient SettingCLINICAL PERSPECTIVE, Circulation, vol.133, issue.23, pp.2254-2262, 2016.
DOI : 10.1161/CIRCULATIONAHA.115.020729

M. Packer, Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure, Journal of Cardiac Failure, vol.7, issue.2, pp.176-182, 2001.
DOI : 10.1054/jcaf.2001.25652

.. ,

C. Green, C. Porter, D. Bresnahan, and J. Spertus, Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure, Journal of the American College of Cardiology, vol.35, issue.5, pp.1245-1255, 2000.
DOI : 10.1016/S0735-1097(00)00531-3

A. Moss, W. Hall, D. Cannom, H. Klein, M. Brown et al., Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events, New England Journal of Medicine, vol.361, issue.14, pp.1329-1338, 2009.
DOI : 10.1056/NEJMoa0906431

C. Linde, W. Abraham, M. Gold, S. Sutton, M. Ghio et al., Randomized Trial of Cardiac Resynchronization in Mildly Symptomatic Heart Failure Patients and in Asymptomatic Patients With Left Ventricular Dysfunction and Previous Heart Failure Symptoms, Journal of the American College of Cardiology, vol.52, issue.23, pp.1834-1843, 2008.
DOI : 10.1016/j.jacc.2008.08.027

A. Tang, G. Wells, M. Talajic, M. Arnold, R. Sheldon et al., Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure, New England Journal of Medicine, vol.363, issue.25, pp.2385-2395, 2010.
DOI : 10.1056/NEJMoa1009540

J. Cleland, W. Abraham, C. Linde, M. Gold, J. Young et al., An individual patient meta-analysis of five randomized trials assessing the effects of cardiac resynchronization therapy on morbidity and mortality in patients with symptomatic heart failure, European Heart Journal, vol.361, issue.14, pp.3547-3556, 2013.
DOI : 10.1056/NEJMoa0906431

K. Lan and D. Demets, Discrete Sequential Boundaries for Clinical Trials, Biometrika, vol.70, issue.3, pp.659-663, 1983.
DOI : 10.2307/2336502

O. Brien, P. Fleming, and T. , A Multiple Testing Procedure for Clinical Trials, Biometrics, vol.35, issue.3, pp.549-556, 1979.
DOI : 10.2307/2530245

G. Hommel, A stagewise rejective multiple test procedure based on a modified Bonferroni test, Biometrika, vol.75, issue.2, pp.383-386, 1988.
DOI : 10.1093/biomet/75.2.383

D. Martin, B. Lemke, K. Aonuma, H. Krum, L. Lee et al., Clinical outcomes with adaptive cardiac resynchronization therapy: long-term outcomes of the adaptive CRT trial, HFSA Late Breakers [Abstract]. 23, 2013.

G. Filippatos, S. Anker, M. Bohm, M. Gheorghiade, L. Kober et al., A randomized controlled study of finerenone vs. eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney disease, European Heart Journal, vol.37, issue.27, pp.2105-2114, 2016.
DOI : 10.1159/000368746

M. Gheorghiade, P. Pang, A. Ambrosy, G. Lan, P. Schmidt et al., A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90??days: analysis from the EVEREST trial, Heart Failure Reviews, vol.148, issue.3, pp.485-509, 2012.
DOI : 10.1016/j.ahj.2004.03.004

J. Butler, M. Gheorghiade, A. Kelkar, G. Fonarow, S. Anker et al., In-hospital worsening heart failure, European Journal of Heart Failure, vol.14, issue.11, pp.1104-1113, 2015.
DOI : 10.1016/j.cardfail.2008.08.010

M. Stockburger, A. Moss, H. Klein, W. Zareba, I. Goldenberg et al., Sustained clinical benefit of cardiac resynchronization therapy in non-LBBB patients with prolonged PR-interval: MADIT-CRT long-term follow-up, Clinical Research in Cardiology, vol.105, issue.4
DOI : 10.1007/s00392-015-0926-0

, Clin Res Cardiol, vol.105, pp.944-952, 2016.