Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position
Abstract
The palladium-catalyzed direct arylation of benzofurazans with aryl bromides to access 4-ary-lbenzofurazans proceeds in moderate-to-high yields using phosphine-free palladium acetate as the catalyst and potassium acetate as an inexpensive base. A wide variety of (hetero) aryl bromides, including bromopyridine and bromothiophene derivatives has been successfully employed. Palladium-catalyzed one-pot C-4, C-7-diarylation of benzofurazan was also achieved using a larger amount of aryl bromide. Moreover, the derivatization of 4-arylbenzofurazans into 4-arylquinaxolines is also reported.
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Idris et al. -2017- Palladium-Catalyzed Regioselective Direct Arylatio.pdf (362.43 Ko)
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adsc201700435-sup-0001-misc_information.pdf (3.8 Mo)
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)