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Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position

Abstract : The palladium-catalyzed direct arylation of benzofurazans with aryl bromides to access 4-ary-lbenzofurazans proceeds in moderate-to-high yields using phosphine-free palladium acetate as the catalyst and potassium acetate as an inexpensive base. A wide variety of (hetero) aryl bromides, including bromopyridine and bromothiophene derivatives has been successfully employed. Palladium-catalyzed one-pot C-4, C-7-diarylation of benzofurazan was also achieved using a larger amount of aryl bromide. Moreover, the derivatization of 4-arylbenzofurazans into 4-arylquinaxolines is also reported.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578528
Contributor : Laurent Jonchère <>
Submitted on : Monday, September 11, 2017 - 3:00:12 PM
Last modification on : Friday, July 10, 2020 - 4:00:46 PM

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Imane Idris, Fazia Derridj, Jean-François Soulé, Henri Doucet. Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2017, 359 (14), pp.2448-2456. ⟨10.1002/adsc.201700435⟩. ⟨hal-01578528⟩

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