Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position

Imane Idris; Fazia Derridj; Jean-François Soule; Henri Doucet

doi:10.1002/adsc.201700435

Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position

Imane Idris ^{1, 2} Fazia Derridj ¹ Jean-François Soule ² Henri Doucet ²

1 LPCM - Laboratoire de physique et de chimie des matériaux [Tizi-Ouzou]

2 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : The palladium-catalyzed direct arylation of benzofurazans with aryl bromides to access 4-ary-lbenzofurazans proceeds in moderate-to-high yields using phosphine-free palladium acetate as the catalyst and potassium acetate as an inexpensive base. A wide variety of (hetero) aryl bromides, including bromopyridine and bromothiophene derivatives has been successfully employed. Palladium-catalyzed one-pot C-4, C-7-diarylation of benzofurazan was also achieved using a larger amount of aryl bromide. Moreover, the derivatization of 4-arylbenzofurazans into 4-arylquinaxolines is also reported.

Keywords : quinaxolines benzofurazans catalysis c-h activation palladium

Type de document :

Article dans une revue

Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2017, 359 (14), pp.2448-2456. 〈10.1002/adsc.201700435〉

Domaine :

Chimie / Chimie organique

Chimie / Catalyse

Liste complète des métadonnées

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578528
Contributeur : Laurent Jonchère <>
Soumis le : lundi 11 septembre 2017 - 15:00:12
Dernière modification le : samedi 24 mars 2018 - 01:38:42

Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position

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Palladium-Catalyzed Regioselective Direct Arylation of Benzofurazans at the C-4 Position

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