Direct C3-Arylation of 2H-Indazole Derivatives with Aryl Bromides by using Low Loading of a Phosphine-free Palladium Catalyst

Abstract : The palladium-catalyzed direct arylation of 2 H-indazoles with aryl bromides for the preparation of 3-aryl-2 H-indazoles was found to proceed in high yields when using only 0.5–0.1 mol % Pd(OAc)2 catalyst and KOAc as inexpensive base. A wide variety of electron-deficient and electron-rich aryl bromides and also heteroaryl bromides has been successfully employed. Both electron-withdrawing and electron-donating substituents on the 2 H-indazoles are also tolerated. Moreover, the reaction can be performed in the “green” solvent cyclopentyl methyl ether.
Type de document :
Article dans une revue
ChemCatChem, Wiley, 2017, 9 (12), pp.2239--2249. 〈10.1002/cctc.201601420〉
Liste complète des métadonnées

Littérature citée [11 références]  Voir  Masquer  Télécharger

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578529
Contributeur : Laurent Jonchère <>
Soumis le : jeudi 28 septembre 2017 - 10:01:47
Dernière modification le : vendredi 25 mai 2018 - 01:25:50
Document(s) archivé(s) le : vendredi 29 décembre 2017 - 13:27:29

Fichier

Doucet et al. - 2016 - Direct ...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Fatma Belkessam, Mohand Aidene, Jean-François Soulé, Henri Doucet. Direct C3-Arylation of 2H-Indazole Derivatives with Aryl Bromides by using Low Loading of a Phosphine-free Palladium Catalyst. ChemCatChem, Wiley, 2017, 9 (12), pp.2239--2249. 〈10.1002/cctc.201601420〉. 〈hal-01578529〉

Partager

Métriques

Consultations de la notice

88

Téléchargements de fichiers

37