Copper-Catalyzed Oxidative Dehydrogenative C(sp(3))-H Bond Amination of (Cyclo) Alkanes using NH-Heterocycles as Amine Sources
Abstract
A copper-catalyzed oxidative C(sp(3))-H/N-H coupling of NH-heterocycles with affordable (cyclo) alkanes has been developed. This procedure involves C(sp(3))-N bond formation through a radical pathway generated by homolytic cleavage of di-tert-butyl peroxide and trapping of the radical(s) by copper catalysts. The reaction tolerates a series of functional groups, such as bromo, fluoro, ester, ketone, nitrile, methyl, and methoxy. free-NH-containing indoles, pyrroles, pyrazoles, indazoles, and benzotriazoles are successfully N-alkylated.
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Wang et al. - Copper-Catalyzed Oxidative Dehydrogenative C(sp3)-.pdf (966.67 Ko)
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cssc201700783-sup-0001-misc_information.pdf (2.96 Mo)
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)