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Journal articles
Copper-Catalyzed Oxidative Dehydrogenative C(sp(3))-H Bond Amination of (Cyclo) Alkanes using NH-Heterocycles as Amine Sources
Abstract : A copper-catalyzed oxidative C(sp(3))-H/N-H coupling of NH-heterocycles with affordable (cyclo) alkanes has been developed. This procedure involves C(sp(3))-N bond formation through a radical pathway generated by homolytic cleavage of di-tert-butyl peroxide and trapping of the radical(s) by copper catalysts. The reaction tolerates a series of functional groups, such as bromo, fluoro, ester, ketone, nitrile, methyl, and methoxy. free-NH-containing indoles, pyrroles, pyrazoles, indazoles, and benzotriazoles are successfully N-alkylated.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578538
Contributor : Laurent Jonchère <>
Submitted on : Monday, September 11, 2017 - 4:31:54 PM
Last modification on : Wednesday, January 13, 2021 - 3:08:06 AM
Contributor : Laurent Jonchère <>
Submitted on : Monday, September 11, 2017 - 4:31:54 PM
Last modification on : Wednesday, January 13, 2021 - 3:08:06 AM