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Journal Articles Organic & Biomolecular Chemistry Year : 2017

One-step synthesis of conjugated enynenitriles from bromocyanoacetylene

Abstract

The chemical reactivity of bromocyanoacetylene has been evaluated for the first time by making it react with terminal alkynes and secondary amines in the presence of bis( triphenylphosphine) palladium dichloride and copper iodide as co-catalysts. This reaction provides new conjugated enynenitriles stereoselectively in one step in variable yields.
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Dates and versions

hal-01578550 , version 1 (13-09-2017)

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Romain Ligny, Etienne S. Gauthier, Manuel Yanez, Thierry Roisnel, Jean-Claude Guillemin, et al.. One-step synthesis of conjugated enynenitriles from bromocyanoacetylene. Organic & Biomolecular Chemistry, 2017, 15 (28), pp.6050-6056. ⟨10.1039/c6ob02590k⟩. ⟨hal-01578550⟩
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